An assessment of the utility of unselected coagulation screening in general hospital practice.
AffiliationDepartment of Haematology, Mid Western Regional Hospital, Limerick, Ireland. firstname.lastname@example.org
Partial Thromboplastin Time
MetadataShow full item record
CitationAn assessment of the utility of unselected coagulation screening in general hospital practice. 2011, 22 (2):106-9 Blood Coagul. Fibrinolysis
JournalBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
AbstractCoagulation screening using prothrombin time (PT) and activated partial thromboplastin time (APTT) is widely used. We performed an audit of coagulation screening in an Irish teaching hospital. We analysed PT and/or APTT results received during normal working hours during a 1-week period in our hospital. Abnormal results due to anticoagulants were excluded from further study. In samples with PT longer than 15.5 s and/or APTT longer than 42 s, we proceeded to 1: 1 mixing studies if the PT was prolonged and 1: 1 mixing studies, factor XII assay and lupus screen if the APTT was prolonged. We also obtained referral source for all samples and clinical details for abnormal samples. Six hundred and seventy-one coagulation requests were received during the study period. Three hundred and eighteen of 671 (47.4%) coagulation requests were for monitoring of anticoagulation. Three hundred and fifty-three of 671 (52.6%) requests were for coagulation screening rather than anticoagulant monitoring. In the coagulation screens received, PT was prolonged in 19 of 353 (5.4%). PT was longer than 20 s in four of 353 cases (1.1%). APTT was prolonged in 19 of 353 (5.4%). APTT was longer than 50 s in four of 353 (1.1%). No patients with abnormal PT or APTT had any bleeding sequelae during the study period. Unregulated coagulation screening has a low yield of abnormal results; the majority of these abnormal results show mild prolongation of PT or APTT with no evidence that they are associated with an increased bleeding risk.
- On-site prothrombin time, activated partial thromboplastin time, and platelet count. A comparison between whole blood and laboratory assays with coagulation factor analysis in patients presenting for cardiac surgery.
- Authors: Despotis GJ, Santoro SA, Spitznagel E, Kater KM, Barnes P, Cox JL, Lappas DG
- Issue date: 1994 Feb
- [Investigation of coagulation time: PT and APTT].
- Authors: Ramakers C, van der Heul C, van Wijk EM
- Issue date: 2012
- Intraoperative measurement of activated partial thromboplastin time and prothrombin time by a portable laser photometer in patients following cardiopulmonary bypass.
- Authors: Nuttall GA, Oliver WC Jr, Beynen FM, Dull JJ, Murray MJ, Nichols WL
- Issue date: 1993 Aug
- Diagnostic uses of the activated partial thromboplastin time and prothrombin time.
- Authors: Suchman AL, Griner PF
- Issue date: 1986 Jun
- Causes of isolated prolonged activated partial thromboplastin time in an acute care general hospital.
- Authors: Chng WJ, Sum C, Kuperan P
- Issue date: 2005 Sep