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dc.contributor.authorQuinn, Colin
dc.contributor.authorUzbeck, Mateen
dc.contributor.authorSaleem, Imran
dc.contributor.authorCotter, Paul
dc.contributor.authorAli, Javed
dc.contributor.authorO'Malley, Grainne
dc.contributor.authorGilmartin, J J
dc.contributor.authorO'Keeffe, Shaun T
dc.date.accessioned2011-07-11T13:49:47Z
dc.date.available2011-07-11T13:49:47Z
dc.date.issued2011-03
dc.identifier.citationIron status and chronic kidney disease predict restless legs syndrome in an older hospital population. 2011, 12 (3):295-301 Sleep Med.en
dc.identifier.issn1878-5506
dc.identifier.pmid21317036
dc.identifier.doi10.1016/j.sleep.2010.08.014
dc.identifier.urihttp://hdl.handle.net/10147/135763
dc.description.abstractIron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and serum ferritin measurement, using a cutoff of 45-50ng/ml, is widely recommended as the optimal screening test for iron deficiency in RLS. Serum ferritin often increases with inflammation, and a higher cutoff may be better in those with acute and chronic inflammatory conditions, including those with chronic kidney disease (CKD).
dc.description.abstractThe relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more. Diagnosis of RLS was based on a clinician interview.
dc.description.abstractOf 301 patients, 55 (18.3%) had RLS. Ferritin levels less than 40ng/ml and between 40 and 69ng/ml and Stage 4 CKD (estimated glomerular filtration rate [eGFR] between 15 and 29ml/min and not on dialysis) were associated with significantly higher odds for RLS in univariate and multivariate analyses.
dc.description.abstractIron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients. Ferritin less than 70ng/ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions. Independent of iron status, RLS is strongly associated with chronic kidney disease that is not severe enough to require dialysis, and the results of this study suggest that eGFR values and stages of CKD should be reported in future studies of RLS.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21317036en
dc.subject.meshAcute Disease
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAging
dc.subject.meshAnemia, Iron-Deficiency
dc.subject.meshChronic Disease
dc.subject.meshFemale
dc.subject.meshFerritins
dc.subject.meshGlomerulosclerosis, Focal Segmental
dc.subject.meshHospitalization
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshIron
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPredictive Value of Tests
dc.subject.meshPrevalence
dc.subject.meshROC Curve
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshRestless Legs Syndrome
dc.subject.meshRisk Factors
dc.titleIron status and chronic kidney disease predict restless legs syndrome in an older hospital population.en
dc.typeArticleen
dc.contributor.departmentDepartments of Geriatric Medicine, Merlin Park University Hospital, Galway, Ireland.en
dc.identifier.journalSleep medicineen
dc.description.provinceConnacht
html.description.abstractIron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and serum ferritin measurement, using a cutoff of 45-50ng/ml, is widely recommended as the optimal screening test for iron deficiency in RLS. Serum ferritin often increases with inflammation, and a higher cutoff may be better in those with acute and chronic inflammatory conditions, including those with chronic kidney disease (CKD).
html.description.abstractThe relationships between RLS and potential secondary causes were examined in hospital patients aged 50years or more. Diagnosis of RLS was based on a clinician interview.
html.description.abstractOf 301 patients, 55 (18.3%) had RLS. Ferritin levels less than 40ng/ml and between 40 and 69ng/ml and Stage 4 CKD (estimated glomerular filtration rate [eGFR] between 15 and 29ml/min and not on dialysis) were associated with significantly higher odds for RLS in univariate and multivariate analyses.
html.description.abstractIron deficiency and chronic kidney disease are the strongest predictors of RLS in older hospital patients. Ferritin less than 70ng/ml is the best cutoff for identifying possible iron deficiency in RLS patients with inflammatory conditions. Independent of iron status, RLS is strongly associated with chronic kidney disease that is not severe enough to require dialysis, and the results of this study suggest that eGFR values and stages of CKD should be reported in future studies of RLS.


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