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    Proposed new approach for treating Paget's disease of bone.

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    Authors
    Mahmood, W
    McKenna, M J
    Affiliation
    St. Michaels Hospital, Lower George's Street, Dún Laoghaire, Co. Dublin, Ireland.
    Issue Date
    2011-03
    MeSH
    Adult
    Aged
    Aged, 80 and over
    Algorithms
    Bone Density Conservation Agents
    Diphosphonates
    Female
    Humans
    Male
    Middle Aged
    Osteitis Deformans
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    Citation
    Proposed new approach for treating Paget's disease of bone. 2011, 180 (1):121-4 Ir J Med Sci
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/135457
    DOI
    10.1007/s11845-010-0652-6
    PubMed ID
    21132539
    Additional Links
    http://www.ncbi.nlm.nih.gov/pubmed/21132539
    Abstract
    Paget's disease of the bone (PDB) is a localized disorder of bone remodeling. Nitrogen-containing bisphosphonates (N-BPs) are the treatment of choice.
    We aimed to determine the effectiveness of N-BPs in our practice.
    We prospectively tabulated clinical, imaging and biochemical data as well as interventions.
    All patients (n = 31) received one or more different N-BPs such as alendronate, risedronate, and zoledronic acid (ZA). Median (absolute range) serum total alkaline phosphatase (ALP) declined from 302 (55-1,600) to 69 (37-101) IU/L. In a subgroup of patients (n = 18) who received ZA after receiving an oral N-BP, median serum total ALP declined from 197 (44-1, 603) to 65 (37-95) IU/L.
    Newly diagnosed patients with PDB should be treated for 6 months with oral N-BPs prior to administration of intravenous ZA. Repeat ZA infusions are necessary only if the serum total ALP levels rise above normal, or if symptoms or complications attributable to PDB persist.
    Item Type
    Article
    Language
    en
    ISSN
    1863-4362
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-010-0652-6
    Scopus Count
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