Show simple item record

dc.contributor.authorNí Chróinín, Danielle
dc.contributor.authorCallaly, Elizabeth L
dc.contributor.authorDuggan, Joseph
dc.contributor.authorMerwick, Áine
dc.contributor.authorHannon, Niamh
dc.contributor.authorSheehan, Órla
dc.contributor.authorMarnane, Michael
dc.contributor.authorHorgan, Gillian
dc.contributor.authorWilliams, Emma B
dc.contributor.authorHarris, Dawn
dc.contributor.authorKyne, Lorraine
dc.contributor.authorMcCormack, Patricia M E
dc.contributor.authorMoroney, Joan
dc.contributor.authorGrant, Tim
dc.contributor.authorWilliams, David
dc.contributor.authorDaly, Leslie
dc.contributor.authorKelly, Peter J
dc.date.accessioned2011-07-06T09:29:26Z
dc.date.available2011-07-06T09:29:26Z
dc.date.issued2011-04
dc.identifier.citationAssociation between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. 2011, 42 (4):1021-9 Strokeen
dc.identifier.issn1524-4628
dc.identifier.pmid21372311
dc.identifier.doi10.1161/STROKEAHA.110.596734
dc.identifier.urihttp://hdl.handle.net/10147/135413
dc.description.abstractStatins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study.
dc.description.abstractA population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year.
dc.description.abstractOf 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year).
dc.description.abstractStatin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21372311en
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBrain Ischemia
dc.subject.meshCholesterol
dc.subject.meshCohort Studies
dc.subject.meshComorbidity
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshRecovery of Function
dc.subject.meshStroke
dc.subject.meshSurvival Rate
dc.subject.meshTime
dc.titleAssociation between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study.en
dc.typeArticleen
dc.contributor.departmentNeurovascular Clinical Science Unit, Catherine McCauley Research Centre, Mater University Hospital, Nelson Street, Dublin 7, Ireland. dmmnic@umail.ucc.ieen
dc.identifier.journalStroke; a journal of cerebral circulationen
dc.description.provinceLeinster
html.description.abstractStatins improve infarct volume and neurological outcome in animal stroke models. We investigated the relationship between statin therapy and ischemic stroke outcome in the North Dublin Population Stroke Study.
html.description.abstractA population-based prospective cohort study was performed using rigorous ascertainment methods. Prestroke and acute (≤72 hours) poststroke medications were recorded. Modified Rankin score and fatality were assessed at 7, 28, and 90 days and 1 year.
html.description.abstractOf 448 ischemic stroke patients, statins were prescribed before stroke onset in 30.1% (134/445) and were begun acutely (≤72 hours) in an additional 42.5% (189/445). On logistic regression analysis, adjusting for age, prestroke disability (modified Rankin scale), NIHSS score, hypertension, and aspirin, new poststroke statin therapy was independently associated with improved early and late survival (compared with statin untreated patients: OR for death, 0.12; CI, 0.03-0.54 at 7 days; OR, 0.19; CI, 0.07-0.48 at 90 days; OR, 0.26; CI, 0.12-0.55 at 1 year; P≤0.006 for all). Similar findings were observed for statin therapy before stroke onset (adjusted OR for death compared with statin-untreated-patients, 0.04; CI, 0.00-0.33; P=0.003 at 7 days; OR, 0.23; CI, 0.09-0.58; P=0.002 at 90 days; OR, 0.48; CI, 0.23-1.01; P=0.05 at 1 year).
html.description.abstractStatin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies. Randomized trials of statin therapy for treatment of acute stroke are needed.


This item appears in the following Collection(s)

Show simple item record