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    Preadipocyte factor-1 is associated with metabolic profile in severe obesity.

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    Authors
    O'Connell, J
    Lynch, L
    Hogan, A
    Cawood, T J
    O'Shea, D
    Affiliation
    Department of Endocrinology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. jeanoco@gmail.com
    Issue Date
    2011-04
    MeSH
    Adipocytes
    Adult
    Bariatric Surgery
    Case-Control Studies
    Cell Count
    Cell Size
    Cross-Sectional Studies
    Female
    Health
    Humans
    Inflammation Mediators
    Intercellular Signaling Peptides and Proteins
    Macrophages
    Male
    Membrane Proteins
    Metabolome
    Middle Aged
    Obesity, Morbid
    Severity of Illness Index
    Young Adult
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    Citation
    Preadipocyte factor-1 is associated with metabolic profile in severe obesity. 2011, 96 (4):E680-4 J. Clin. Endocrinol. Metab.
    Journal
    The Journal of clinical endocrinology and metabolism
    URI
    http://hdl.handle.net/10147/135060
    DOI
    10.1210/jc.2010-2026
    PubMed ID
    21252254
    Additional Links
    http://www.ncbi.nlm.nih.gov/pubmed/21252254
    Abstract
    Dysfunctional adipose tissue has been proposed as a key pathological process linking obesity and metabolic disease. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals.
    We hypothesized that adipose tissue from metabolically healthy obese (MHO) and matched metabolically unhealthy obese individuals would demonstrate distinct differences in relation to Pref-1 expression, adipocyte size, and inflammatory markers.
    This was a cross-sectional study, investigating obese patients undergoing bariatric surgery at a tertiary referral centre. Patients included 12 MHO and 17 age- and body mass index-matched metabolically unhealthy obese individuals. Main Outcome Measures: Pref-1, monocyte chemotactic protein-1, TNF-α, granulocyte colony-stimulating factor, IL-6, and adiponectin levels, macrophage numbers, and adipocyte size were measured in omental and subcutaneous adipose tissue.
    The MHO group had a lower level of Pref-1 (per 1000 adipocytes) in both subcutaneous [160 (136-177) versus 194 (153-355); P < 0.05] and omental adipose tissue [102 (32-175) versus 194 (100-350); P < 0.005]. This was associated with lower numbers of macrophages, lower levels of TNF-α, monocyte chemotactic protein-1, and granulocyte colony-stimulating factor, and higher levels of adiponectin. Omental Pref-1 showed strong correlations with adipocyte size (r = 0.67, P < 0.0005) and metabolic and adipokine parameters, including percent fatty liver (r = 0.62, P < 0.005), fasting glucose (r = 0.68, P < 0.0005), triglyceride (r = 0.60, P < 0.005), high-density lipoprotein cholesterol (r = -0.46, P < 0.05), and adiponectin (r = -0.71, P < 0.05).
    Adipose tissue in MHO individuals had lower levels of Pref-1, a known inhibitor of preadipocyte differentiation, and a more favorable inflammatory profile. These factors may be key to protecting this subgroup of obese individuals from the adverse metabolic profile associated with excess adiposity.
    Item Type
    Article
    Language
    en
    ISSN
    1945-7197
    ae974a485f413a2113503eed53cd6c53
    10.1210/jc.2010-2026
    Scopus Count
    Collections
    St. Vincent's University Hospital

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