Show simple item record

dc.contributor.authorMylotte, Darren
dc.contributor.authorFoley, David
dc.contributor.authorKenny, Dermot
dc.date.accessioned2011-05-30T15:23:46Z
dc.date.available2011-05-30T15:23:46Z
dc.date.issued2011-01
dc.identifier.citationPlatelet function testing: methods of assessment and clinical utility. 2011, 9 (1):14-24 Cardiovasc Hematol Agents Med Chemen
dc.identifier.issn1875-6182
dc.identifier.pmid21121898
dc.identifier.urihttp://hdl.handle.net/10147/132323
dc.description.abstractPlatelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21121898en
dc.subject.meshBlood Platelets
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshPlatelet Activation
dc.subject.meshPlatelet Aggregation
dc.subject.meshPlatelet Function Tests
dc.subject.meshThrombelastography
dc.titlePlatelet function testing: methods of assessment and clinical utility.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cardiology, Beaumont Hospital, Dublin, Ireland. darrenmylotte@rcsi.ieen
dc.identifier.journalCardiovascular & hematological agents in medicinal chemistryen
dc.description.provinceLeinster
html.description.abstractPlatelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.


Files in this item

Thumbnail
Name:
21121898.txt
Size:
1.189Kb
Format:
Text file

This item appears in the following Collection(s)

Show simple item record