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    Human bovine tuberculosis - remains in the differential.

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    Authors
    Bilal, Shaukat
    Iqbal, Mudassir
    Murphy, Philip
    Power, Joan
    Affiliation
    Department of Respiratory Medicine, Naas General Hospital, Trinity College Dublin, Kildare, Ireland. sb72pk@yahoo.com
    Issue Date
    2010-11
    MeSH
    Adult
    Antitubercular Agents
    Drug Resistance, Bacterial
    Female
    Humans
    Isoniazid
    Male
    Microbial Sensitivity Tests
    Middle Aged
    Mycobacterium bovis
    Pyrazinamide
    Radiography, Thoracic
    Tomography, X-Ray Computed
    Treatment Outcome
    Tuberculosis
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    Citation
    Human bovine tuberculosis - remains in the differential. 2010, 59 (Pt 11):1379-82 J. Med. Microbiol.
    Journal
    Journal of medical microbiology
    URI
    http://hdl.handle.net/10147/132284
    DOI
    10.1099/jmm.0.020511-0
    PubMed ID
    20688950
    Additional Links
    http://jmm.sgmjournals.org/cgi/content/full/59/11/1379
    Abstract
    Mycobacterium bovis is a pathogen of cattle. The unpasteurized milk of affected cattle is a source of infection in humans. Despite the screening of cattle and the pasteurization of milk, M bovis has not been eradicated. A high index of clinical suspicion is needed in symptomatic patients with a history of possible exposure. At risk groups include animal workers, farmers, meat packers, vets and zoo keepers. Humans are usually infected by the aerosol route. We present two cases of human bovine tuberculosis. One was a presumptive case and the second was a confirmed case. Both responded well to antituberculous therapy. In the confirmed case, there was evidence of transmission to the partner living in the same house. Rifampicin prophylaxis was given to the exposed case. The M. bovis from the confirmed case was isoniazid resistant, in addition to having the well known resistance to pyrazinamide. Isoniazid resistance has been described before in those who are immunocompromised. We describe it in an immunocompetent patient.
    Item Type
    Article
    Language
    en
    ISSN
    1473-5644
    ae974a485f413a2113503eed53cd6c53
    10.1099/jmm.0.020511-0
    Scopus Count
    Collections
    Naas General Hospital

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