Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).
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Authors
Walsh, LorraineGillham, Charles
Dunne, Mary
Fraser, Ian
Hollywood, Donal
Armstrong, John
Thirion, Pierre
Affiliation
Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland.Issue Date
2011-01MeSH
AdultAged
Antibodies, Monoclonal
Antineoplastic Agents
Carcinoma
Cisplatin
Combined Modality Therapy
Female
Head and Neck Neoplasms
Humans
Male
Middle Aged
Neoplasms, Squamous Cell
Patient Compliance
Radiotherapy Dosage
Retrospective Studies
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Show full item recordCitation
Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). 2011, 98 (1):38-41 Radiother OncolPublisher
ElsevierJournal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyDOI
10.1016/j.radonc.2010.11.009PubMed ID
21159400Abstract
We retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.Item Type
ArticleLanguage
enISSN
1879-0887ae974a485f413a2113503eed53cd6c53
10.1016/j.radonc.2010.11.009