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    Bioluminescent imaging: a critical tool in pre-clinical oncology research.

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    Authors
    O'Neill, Karen
    Lyons, Scott K
    Gallagher, William M
    Curran, Kathleen M
    Byrne, Annette T
    Affiliation
    UCD School of Medicine and Medical Science, Health Science Building, University College Dublin, Belfield, Dublin 4, Ireland.
    Issue Date
    2010-02
    MeSH
    Animals
    Disease Models, Animal
    Disease Progression
    Luciferases
    Luminescent Measurements
    Mice
    Neoplasm Metastasis
    Neoplasms, Experimental
    
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    Citation
    Bioluminescent imaging: a critical tool in pre-clinical oncology research. 2010, 220 (3):317-27 J. Pathol.
    Journal
    The Journal of pathology
    URI
    http://hdl.handle.net/10147/129689
    DOI
    10.1002/path.2656
    PubMed ID
    19967724
    Abstract
    Bioluminescent imaging (BLI) is a non-invasive imaging modality widely used in the field of pre-clinical oncology research. Imaging of small animal tumour models using BLI involves the generation of light by luciferase-expressing cells in the animal following administration of substrate. This light may be imaged using an external detector. The technique allows a variety of tumour-associated properties to be visualized dynamically in living models. The increasing use of BLI as a small-animal imaging modality has led to advances in the development of xenogeneic, orthotopic, and genetically engineered animal models expressing luciferase genes. This review aims to provide insight into the principles of BLI and its applications in cancer research. Many studies to assess tumour growth and development, as well as efficacy of candidate therapeutics, have been performed using BLI. More recently, advances have also been made using bioluminescent imaging in studies of protein-protein interactions, genetic screening, cell-cycle regulators, and spontaneous cancer development. Such novel studies highlight the versatility and potential of bioluminescent imaging in future oncological research.
    Item Type
    Article
    Language
    en
    ISSN
    1096-9896
    ae974a485f413a2113503eed53cd6c53
    10.1002/path.2656
    Scopus Count
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