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dc.contributor.authorGallagher, Damien
dc.contributor.authorCoen, Robert
dc.contributor.authorKilroy, Dana
dc.contributor.authorBelinski, Kate
dc.contributor.authorBruce, Irene
dc.contributor.authorCoakley, Davis
dc.contributor.authorWalsh, Bernard
dc.contributor.authorCunningham, Conal
dc.contributor.authorLawlor, Brian A
dc.date.accessioned2011-05-11T11:14:48Z
dc.date.available2011-05-11T11:14:48Z
dc.date.issued2011-02
dc.identifier.citationAnxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. 2011, 26 (2):166-72 Int J Geriatr Psychiatryen
dc.identifier.issn1099-1166
dc.identifier.pmid21229599
dc.identifier.doi10.1002/gps.2509
dc.identifier.urihttp://hdl.handle.net/10147/129395
dc.description.abstractDepression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology.
dc.description.abstractOne hundred and sixty-one patients with MCI were identified from consecutive referrals to a memory clinic. Univariate, multivariate and cox regression analyses were conducted.
dc.description.abstractSeventy-six per cent of all patients had at least one neuropsychiatric symptom at baseline of which anxiety (52%), affective disturbance (37%) and aggression (32%) were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline.
dc.description.abstractNeuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of earlier conversion to AD. However, these findings were not independent of cognitive status at baseline and therefore may be markers of severity rather than independent predictors of disease progression.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAlzheimer Disease
dc.subject.meshAnxiety
dc.subject.meshBehavioral Symptoms
dc.subject.meshCognition Disorders
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeuropsychological Tests
dc.subject.meshPredictive Value of Tests
dc.subject.meshSeverity of Illness Index
dc.titleAnxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment.en
dc.typeArticleen
dc.contributor.departmentMercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland. gallagherdamien@hotmail.comen
dc.identifier.journalInternational journal of geriatric psychiatryen
dc.description.provinceLeinster
html.description.abstractDepression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology.
html.description.abstractOne hundred and sixty-one patients with MCI were identified from consecutive referrals to a memory clinic. Univariate, multivariate and cox regression analyses were conducted.
html.description.abstractSeventy-six per cent of all patients had at least one neuropsychiatric symptom at baseline of which anxiety (52%), affective disturbance (37%) and aggression (32%) were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline.
html.description.abstractNeuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of earlier conversion to AD. However, these findings were not independent of cognitive status at baseline and therefore may be markers of severity rather than independent predictors of disease progression.


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