Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment.
Lawlor, Brian A
AffiliationMercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland. email@example.com
Aged, 80 and over
Predictive Value of Tests
Severity of Illness Index
MetadataShow full item record
CitationAnxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. 2011, 26 (2):166-72 Int J Geriatr Psychiatry
JournalInternational journal of geriatric psychiatry
AbstractDepression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive biomarkers of evolving Alzheimer's pathology.
One hundred and sixty-one patients with MCI were identified from consecutive referrals to a memory clinic. Univariate, multivariate and cox regression analyses were conducted.
Seventy-six per cent of all patients had at least one neuropsychiatric symptom at baseline of which anxiety (52%), affective disturbance (37%) and aggression (32%) were the most common. Increasing symptom frequency was observed with increasing clinical severity. Anticipatory anxiety and activity disturbances were significantly associated with earlier conversion to AD although this association did not remain significant following adjustment for cognitive status at baseline.
Neuropsychiatric symptoms and anxiety symptoms in particular are common in patients with MCI. In this sample anxiety for upcoming events and purposeless activity frequently co-occurred and were significant clinical predictors of earlier conversion to AD. However, these findings were not independent of cognitive status at baseline and therefore may be markers of severity rather than independent predictors of disease progression.
- Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy.
- Authors: Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, Spalletta G
- Issue date: 2010
- Verbal cued recall as a predictor of conversion to Alzheimer's disease in Mild Cognitive Impairment.
- Authors: Dierckx E, Engelborghs S, De Raedt R, Van Buggenhout M, De Deyn PP, Verté D, Ponjaert-Kristoffersen I
- Issue date: 2009 Oct
- Predictors of progression from mild cognitive impairment to Alzheimer disease.
- Authors: Palmer K, Berger AK, Monastero R, Winblad B, Bäckman L, Fratiglioni L
- Issue date: 2007 May 8
- Dependence and caregiver burden in Alzheimer's disease and mild cognitive impairment.
- Authors: Gallagher D, Ni Mhaolain A, Crosby L, Ryan D, Lacey L, Coen RF, Walsh C, Coakley D, Walsh JB, Cunningham C, Lawlor BA
- Issue date: 2011 Mar
- Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study.
- Authors: Ramakers IH, Visser PJ, Aalten P, Kester A, Jolles J, Verhey FR
- Issue date: 2010 Jul