• Login
    View Item 
    •   Home
    • Other Irish Health Organisations
    • Publications
    • View Item
    •   Home
    • Other Irish Health Organisations
    • Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4995
    UlsterS
    4995
    Connacht
    1672
    Munster
    54
    Leinster
    456

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    21085671.pdf
    Size:
    555.9Kb
    Format:
    PDF
    Download
    Authors
    McLaughlin, Russell Lewis
    Phukan, Julie
    McCormack, William
    Lynch, David S
    Greenway, Matthew
    Cronin, Simon
    Saunders, Jean
    Slowik, Agnieska
    Tomik, Barbara
    Andersen, Peter M
    Bradley, Daniel G
    Jakeman, Phil
    Hardiman, Orla
    Show allShow less
    Affiliation
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. mclaugr@tcd.ie
    Issue Date
    2010-11
    MeSH
    Alleles
    Amyotrophic Lateral Sclerosis
    Gene Frequency
    Genetic Predisposition to Disease
    Genotype
    Haplotypes
    Humans
    Ireland
    Linkage Disequilibrium
    Poland
    Polymorphism, Single Nucleotide
    Ribonuclease, Pancreatic
    Sweden
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis. 2010, 5 (11):e15402 PLoS ONE
    Publisher
    PLoS One
    Journal
    PloS one
    URI
    http://hdl.handle.net/10147/129140
    DOI
    10.1371/journal.pone.0015402
    PubMed ID
    21085671
    Abstract
    To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.
    Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls.
    All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p<0.001). An allele dose-dependent regulation of angiogenin levels was observed in controls. This regulation was attenuated in the ALS cohort. A significant positive correlation between CSF plasma angiogenin levels was present in controls and abolished in ALS.
    ANG variants associate with ALS in the Irish and Swedish populations, but not in the Polish. There is evidence of dysregulation of angiogenin expression in plasma and CSF in sporadic ALS. Angiogenin expression is likely to be important in the pathogenesis of ALS.
    Item Type
    Article
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0015402
    Scopus Count
    Collections
    Publications

    entitlement

    Related articles

    • A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy.
    • Authors: Conforti FL, Sprovieri T, Mazzei R, Ungaro C, La Bella V, Tessitore A, Patitucci A, Magariello A, Gabriele AL, Tedeschi G, Simone IL, Majorana G, Valentino P, Condino F, Bono F, Monsurrò MR, Muglia M, Quattrone A
    • Issue date: 2008 Jan
    • Identification of a novel missense mutation in angiogenin in a Chinese amyotrophic lateral sclerosis cohort.
    • Authors: Zou ZY, Wang XN, Liu MS, Sun Q, Li XG, Cui LY, Kong J
    • Issue date: 2012 May
    • Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.
    • Authors: Paubel A, Violette J, Amy M, Praline J, Meininger V, Camu W, Corcia P, Andres CR, Vourc'h P, French Amyotrophic Lateral Sclerosis (ALS) Study Group.
    • Issue date: 2008 Oct
    • Association between the Angiogenin (ANG) K17I variant and amyotrophic lateral sclerosis risk in Caucasian: a meta-analysis.
    • Authors: Pan L, Deng X, Ding D, Leng H, Zhu X, Wang Z
    • Issue date: 2015 Dec
    • CSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum.
    • Authors: Morelli C, Tiloca C, Colombrita C, Zambon A, Soranna D, Lafronza A, Solca F, Carelli L, Poletti B, Doretti A, Verde F, Maderna L, Ticozzi N, Ratti A, Silani V
    • Issue date: 2020 Feb
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.