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dc.contributor.authorFlood, Karen
dc.contributor.authorPeace, Aaron
dc.contributor.authorKent, Etaoin
dc.contributor.authorTedesco, Tony
dc.contributor.authorDicker, Patrick
dc.contributor.authorGeary, Michael
dc.contributor.authorMalone, Fergal D
dc.contributor.authorKenny, Dermot
dc.date.accessioned2011-04-27T15:05:05Z
dc.date.available2011-04-27T15:05:05Z
dc.date.issued2010-09
dc.identifier.citationPlatelet reactivity and pregnancy loss. 2010, 203 (3):281.e1-5 Am. J. Obstet. Gynecol.en
dc.identifier.issn1097-6868
dc.identifier.pmid20684942
dc.identifier.doi10.1016/j.ajog.2010.06.023
dc.identifier.urihttp://hdl.handle.net/10147/128797
dc.description.abstractWe sought to critically evaluate platelet function in recurrent miscarriage (RM).
dc.description.abstractWe conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.
dc.description.abstractAt test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.
dc.description.abstractThis novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.
dc.language.isoenen
dc.relation.urldoi:10.1016/j.ajog.2010.06.023en
dc.subject.meshAbortion, Habitual
dc.subject.meshAdenosine Diphosphate
dc.subject.meshAdult
dc.subject.meshArachidonic Acid
dc.subject.meshCase-Control Studies
dc.subject.meshCollagen Type I
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshEpinephrine
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshPeptide Fragments
dc.subject.meshPlatelet Aggregation
dc.subject.meshPlatelet Function Tests
dc.subject.meshPregnancy
dc.subject.meshPregnancy Trimester, First
dc.subject.meshProspective Studies
dc.titlePlatelet reactivity and pregnancy loss.en
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.en
dc.identifier.journalAmerican journal of obstetrics and gynecologyen
dc.description.provinceLeinster
html.description.abstractWe sought to critically evaluate platelet function in recurrent miscarriage (RM).
html.description.abstractWe conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.
html.description.abstractAt test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.
html.description.abstractThis novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.


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