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    Platelet reactivity and pregnancy loss.

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    Authors
    Flood, Karen
    Peace, Aaron
    Kent, Etaoin
    Tedesco, Tony
    Dicker, Patrick
    Geary, Michael
    Malone, Fergal D
    Kenny, Dermot
    Affiliation
    Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Issue Date
    2010-09
    MeSH
    Abortion, Habitual
    Adenosine Diphosphate
    Adult
    Arachidonic Acid
    Case-Control Studies
    Collagen Type I
    Dose-Response Relationship, Drug
    Epinephrine
    Female
    Humans
    Middle Aged
    Peptide Fragments
    Platelet Aggregation
    Platelet Function Tests
    Pregnancy
    Pregnancy Trimester, First
    Prospective Studies
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    Citation
    Platelet reactivity and pregnancy loss. 2010, 203 (3):281.e1-5 Am. J. Obstet. Gynecol.
    Journal
    American journal of obstetrics and gynecology
    URI
    http://hdl.handle.net/10147/128797
    DOI
    10.1016/j.ajog.2010.06.023
    PubMed ID
    20684942
    Additional Links
    doi:10.1016/j.ajog.2010.06.023
    Abstract
    We sought to critically evaluate platelet function in recurrent miscarriage (RM).
    We conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.
    At test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.
    This novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.
    Item Type
    Article
    Language
    en
    ISSN
    1097-6868
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ajog.2010.06.023
    Scopus Count
    Collections
    Rotunda Hospital

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