Platelet reactivity and pregnancy loss.
Name:
Publisher version
Affiliation
Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.Issue Date
2010-09MeSH
Abortion, HabitualAdenosine Diphosphate
Adult
Arachidonic Acid
Case-Control Studies
Collagen Type I
Dose-Response Relationship, Drug
Epinephrine
Female
HumansMiddle AgedPeptide FragmentsPlatelet AggregationPlatelet Function TestsPregnancyPregnancy Trimester, FirstProspective Studies
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Platelet reactivity and pregnancy loss. 2010, 203 (3):281.e1-5 Am. J. Obstet. Gynecol.Journal
American journal of obstetrics and gynecologyDOI
10.1016/j.ajog.2010.06.023PubMed ID
20684942Additional Links
doi:10.1016/j.ajog.2010.06.023Abstract
We sought to critically evaluate platelet function in recurrent miscarriage (RM).We conducted a prospective study comparing 30 patients with unexplained recurrent first-trimester pregnancy loss with 30 control subjects matched for age and serum progesterone level. Platelet function was determined using a modified assay of light transmission aggregometry with multiple agonists at different concentrations. Dose-response curves were created and half-maximal effective concentration values were calculated.
At test completion the half-maximal effective concentration values for arachidonic acid in the patients with RM were significantly less than in the control subjects (0.153 vs 0.230; P = .0099). The dose-response curves were tightly matched for the other agonists.
This novel measurement of platelet function has demonstrated that patients with unexplained RM have significantly increased platelet aggregation in response to arachidonic acid. The enhanced response to this agonist provides an empirical rationale for the use of aspirin in management of this clinical condition.