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    A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence.

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    Authors
    Farren, Conor K
    Scimeca, Michael
    Wu, Ran
    Malley, Stephanie O
    Affiliation
    Yale University School of Medicine, Department of Psychiatry, Substance Abuse Treatment Unit, 1 Long Wharf, New Haven, CT 06419, United States. cfarren@stpatsmail.com
    Issue Date
    2009-01-01
    MeSH
    Adult
    Age of Onset
    Alcoholism
    Cognitive Therapy
    Combined Modality Therapy
    Double-Blind Method
    Drug Therapy, Combination
    Ethnic Groups
    Female
    Humans
    Male
    Marital Status
    Middle Aged
    Naltrexone
    Narcotic Antagonists
    Patient Compliance
    Patient Selection
    Psychiatric Status Rating Scales
    Psychotherapy
    Serotonin Uptake Inhibitors
    Sertraline
    Treatment Outcome
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    Citation
    A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. 2009, 99 (1-3):317-21 Drug Alcohol Depend
    Journal
    Drug and alcohol dependence
    URI
    http://hdl.handle.net/10147/128777
    DOI
    10.1016/j.drugalcdep.2008.06.006
    PubMed ID
    18644685
    Additional Links
    doi:10.1016/j.drugalcdep.2008.06.006
    Abstract
    Significant preclinical evidence exists for a synergistic interaction between the opioid and the serotonin systems in determining alcohol consumption. Naltrexone, an opiate receptor antagonist, is approved for the treatment of alcohol dependence. This double-blind placebo-controlled study examined whether the efficacy of naltrexone would be augmented by concurrent treatment with sertraline, a selective serotonin receptor uptake inhibitor (SSRI).
    One hundred and thirteen participants meeting DSM IV alcohol dependence criteria, who were abstinent from alcohol between 5 and 30 days, were randomly assigned to receive one of two treatments at two sites. One group received naltrexone 12.5 mg once daily for 3 days, 25 mg once daily for 4 days, and 50 mg once daily for the next 11 weeks, together with placebo sertraline. The other group received naltrexone as outlined and simultaneously received sertraline 50 mg once daily for 2 weeks, followed by 100 mg once daily for 10 weeks. Both groups received group relapse prevention psychotherapy on a weekly basis.
    Compliance and attendance rates were comparable and high. The groups did not differ on the two primary outcomes, time to first drink and time to relapse to heavy drinking, or on secondary treatment outcomes. With the exception of sexual side effects which were more common in the combination group, most adverse events were similar for the two conditions.
    As the doses are tested in combination with specialized behavioral therapy, this study does not provide sufficient evidence for the combined use of sertraline and naltrexone above naltrexone alone.
    Item Type
    Article
    Language
    en
    ISSN
    1879-0046
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.drugalcdep.2008.06.006
    Scopus Count
    Collections
    St. Patrick's University Hospital

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