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    Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania.

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    Authors
    Kravariti, Eugenia
    Reichenberg, Abraham
    Morgan, Kevin
    Dazzan, Paola
    Morgan, Craig
    Zanelli, Jolanta W
    Lappin, Julia M
    Doody, Gillian A
    Harrison, Glynn
    Jones, Peter B
    Murray, Robin M
    Fearon, Paul
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    Affiliation
    Department of Psychiatry, NIHR Biomedical Research Centre, Maudsley NHS Foundation Trust/Institute of Psychiatry, King's College London, Box 58, De Crespigny Park, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uk
    Issue Date
    2009-05
    MeSH
    Adolescent
    Adult
    Affective Disorders, Psychotic
    Bipolar Disorder
    Case-Control Studies
    Cognition Disorders
    Female
    Humans
    Male
    Middle Aged
    Neuropsychological Tests
    Psychiatric Status Rating Scales
    Semantics
    Statistics, Nonparametric
    Verbal Behavior
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    Citation
    Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania. 2009, 11 (3):323-9 Bipolar Disord
    Journal
    Bipolar disorders
    URI
    http://hdl.handle.net/10147/128758
    DOI
    10.1111/j.1399-5618.2009.00673.x
    PubMed ID
    19419389
    Additional Links
    DOI: 10.1111/j.1399-5618.2009.00673.x
    Abstract
    Neurocognitive dysfunction is likely to represent a trait characteristic of bipolar disorder, but the extent to which it comprises 'core' deficits as opposed to those secondary to longstanding illness or intellectual decline is unclear. We investigated neuropsychological performance in an epidemiologically derived sample of patients with a first affective episode with psychotic symptoms and a positive history of mania, compared to community controls.
    Using a nested case-control, population-based study, measures of episodic and working memory, executive function, processing speed, and visual-spatial perception were compared between 35 patients with a first affective episode with psychotic symptoms and a positive history of mania, and 274 community controls, as well as a subgroup of 105 controls matched on current IQ ('good' versus 'poor') and IQ trajectory ('stable', 'declined', or 'improved') with the patients (three controls per case).
    Compared to the extended control sample, probands showed a suggestive deficit in short-term verbal recall, and a significant deficit in semantic fluency. Only the latter was detectable in the comparison with the IQ-matched controls. All other neurocognitive domains showed intact performance or nonsignificant deficits of small effect sizes compared to both control groups. Semantic fluency showed no association with symptoms or duration of untreated illness.
    Patients with a first affective episode with psychotic symptoms and a positive history of mania show an isolated, selective deficit in semantic verbal fluency, against a background of generally preserved neurocognitive function. This pattern seems to contrast with the more widespread neuropsychological dysfunction seen in schizophrenia.
    Language
    en
    ISSN
    1399-5618
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1399-5618.2009.00673.x
    Scopus Count
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    St. Patrick's University Hospital

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