Differing patterns of brain structural abnormalities between black and white patients with their first episode of psychosis.
Authors
Morgan, K DDazzan, P
Morgan, C
Lappin, J
Hutchinson, G
Chitnis, X
Suckling, J
Fearon, P
Jones, P B
Leff, J
Murray, R M
Affiliation
Department of Psychology, University of Westminster, London W1B 2UW, UK. k.d.morgan@wmin.ac.ukIssue Date
2010-07MeSH
AdultAfrican Continental Ancestry Group
Brain
Caribbean Region
Cerebral Ventricles
Corpus Striatum
European Continental Ancestry Group
Female
Great Britain
Humans
Incidence
International Classification of Diseases
Magnetic Resonance Imaging
Male
Prevalence
Psychotic Disorders
Substance-Related Disorders
Metadata
Show full item recordCitation
Differing patterns of brain structural abnormalities between black and white patients with their first episode of psychosis. 2010, 40 (7):1137-47 Psychol MedJournal
Psychological medicineDOI
10.1017/S0033291709991565PubMed ID
19891807Additional Links
DOI: 10.1017/S0033291709991565Abstract
African-Caribbean and black African people living in the UK are reported to have a higher incidence of diagnosed psychosis compared with white British people. It has been argued that this may be a consequence of misdiagnosis. If this is true they might be less likely to show the patterns of structural brain abnormalities reported in white British patients. The aim of this study therefore was to investigate whether there are differences in the prevalence of structural brain abnormalities in white and black first-episode psychosis patients.We obtained dual-echo (proton density/T2-weighted) images from a sample of 75 first-episode psychosis patients and 68 healthy controls. We used high resolution magnetic resonance imaging and voxel-based methods of image analysis. Two separate analyses were conducted: (1) 34 white British patients were compared with 33 white British controls; (2) 41 African-Caribbean and black African patients were compared with 35 African-Caribbean and black African controls.
White British patients and African-Caribbean/black African patients had ventricular enlargement and increased lenticular nucleus volume compared with their respective ethnic controls. The African-Caribbean/black African patients also showed reduced global grey matter and increased lingual gyrus grey-matter volume. The white British patients had no regional or global grey-matter loss compared with their normal ethnic counterparts but showed increased grey matter in the left superior temporal lobe and right parahippocampal gyrus.
We found no evidence in support of our hypothesis. Indeed, the finding of reduced global grey-matter volume in the African-Caribbean/black African patients but not in the white British patients was contrary to our prediction.
Language
enISSN
1469-8978ae974a485f413a2113503eed53cd6c53
10.1017/S0033291709991565
Scopus Count
Collections
Related articles
- Patterns of illness and care over the 5 years following onset of psychosis in different ethnic groups; the GAP-5 study.
- Authors: Ajnakina O, Lally J, Di Forti M, Kolliakou A, Gardner-Sood P, Lopez-Morinigo J, Dazzan P, Pariante CM, Mondelli V, MacCabe J, David AS, Gaughran F, Murray RM, Vassos E
- Issue date: 2017 Sep
- Raised incidence rates of all psychoses among migrant groups: findings from the East London first episode psychosis study.
- Authors: Coid JW, Kirkbride JB, Barker D, Cowden F, Stamps R, Yang M, Jones PB
- Issue date: 2008 Nov
- Barriers to early diagnosis of symptomatic breast cancer: a qualitative study of Black African, Black Caribbean and White British women living in the UK.
- Authors: Jones CE, Maben J, Lucas G, Davies EA, Jack RH, Ream E
- Issue date: 2015 Mar 13
- Lower prevalence of pre-morbid neurological illness in African-Caribbean than White psychotic patients in England.
- Authors: McKenzie K, Jones P, Lewis S, Williams M, Toone B, Sham P, Murray RM
- Issue date: 2002 Oct
- Symptom profiles and explanatory models of first-episode psychosis in African-, Caribbean- and European-origin groups in Ontario.
- Authors: Maraj A, Anderson KK, Flora N, Ferrari M, Archie S, McKenzie KJ, ACE Project Team
- Issue date: 2017 Apr