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    Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations.

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    Authors
    Zanelli, Jolanta
    Reichenberg, Abraham
    Morgan, Kevin
    Fearon, Paul
    Kravariti, Eugenia
    Dazzan, Paola
    Morgan, Craig
    Zanelli, Caroline
    Demjaha, Arsime
    Jones, Peter B
    Doody, Gillian A
    Kapur, Shitij
    Murray, Robin M
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    Affiliation
    Institute of Psychiatry, PO63, Division of Psychological Medicine and Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. jolanta.zanelli@iop.kcl.ac.uk
    Issue Date
    2010-01
    MeSH
    Adolescent
    Adult
    Aged
    Bipolar Disorder
    Case-Control Studies
    Cognition Disorders
    Depressive Disorder, Major
    Diagnosis, Differential
    Female
    Humans
    Male
    Middle Aged
    Neuropsychological Tests
    Psychiatric Status Rating Scales
    Psychometrics
    Psychotic Disorders
    Risk Factors
    Schizophrenia
    Schizophrenic Psychology
    Severity of Illness Index
    Show allShow less
    
    Metadata
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    Citation
    Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. 2010, 167 (1):78-85 Am J Psychiatry
    Journal
    The American journal of psychiatry
    URI
    http://hdl.handle.net/10147/128749
    DOI
    10.1176/appi.ajp.2009.09010118
    PubMed ID
    19952077
    Additional Links
    http://ajp.psychiatryonline.org/cgi/content/full/167/1/78
    Abstract
    Overwhelming evidence suggests that compromised neuropsychological function is frequently observed in schizophrenia. Neurocognitive dysfunction has often been reported in other psychotic disorders, although there are inconsistencies in the literature. In the context of four distinct diagnostic groups, the authors compared neuropsychological performance among patients experiencing their first psychotic episode.
    Data were derived from a population-based, case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia (N=65), bipolar disorder or mania (N=37), depressive psychosis (N=39), or other psychotic disorders (N=46) following index presentation, as well as to healthy comparison subjects (N=177). The presence of specific and generalized cognitive deficits was examined.
    The schizophrenia group presented widespread neuropsychological impairments and performed significantly worse than healthy comparison subjects on most neuropsychological measures. Patients with other psychotic disorders and depressive psychosis also demonstrated widespread impairments. Deficits in patients with bipolar disorder or mania were less pervasive but evident in performance scores on verbal memory and fluency tests. Differences between the four patient groups and healthy comparison subjects and among the patient groups were attenuated after controlling for differences in general cognitive ability (IQ).
    Early in their course, cognitive deficits are present in all psychotic disorders but are most severe and pervasive in schizophrenia and least pervasive in bipolar disorder and mania.
    Item Type
    Article
    Language
    en
    ISSN
    1535-7228
    ae974a485f413a2113503eed53cd6c53
    10.1176/appi.ajp.2009.09010118
    Scopus Count
    Collections
    St. Patrick's University Hospital

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