Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations.
Authors
Zanelli, JolantaReichenberg, Abraham
Morgan, Kevin
Fearon, Paul
Kravariti, Eugenia
Dazzan, Paola
Morgan, Craig
Zanelli, Caroline
Demjaha, Arsime
Jones, Peter B
Doody, Gillian A
Kapur, Shitij
Murray, Robin M
Affiliation
Institute of Psychiatry, PO63, Division of Psychological Medicine and Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. jolanta.zanelli@iop.kcl.ac.ukIssue Date
2010-01MeSH
AdolescentAdult
Aged
Bipolar Disorder
Case-Control Studies
Cognition Disorders
Depressive Disorder, Major
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales
Psychometrics
Psychotic Disorders
Risk Factors
Schizophrenia
Schizophrenic Psychology
Severity of Illness Index
Metadata
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Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. 2010, 167 (1):78-85 Am J PsychiatryJournal
The American journal of psychiatryDOI
10.1176/appi.ajp.2009.09010118PubMed ID
19952077Additional Links
http://ajp.psychiatryonline.org/cgi/content/full/167/1/78Abstract
Overwhelming evidence suggests that compromised neuropsychological function is frequently observed in schizophrenia. Neurocognitive dysfunction has often been reported in other psychotic disorders, although there are inconsistencies in the literature. In the context of four distinct diagnostic groups, the authors compared neuropsychological performance among patients experiencing their first psychotic episode.Data were derived from a population-based, case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia (N=65), bipolar disorder or mania (N=37), depressive psychosis (N=39), or other psychotic disorders (N=46) following index presentation, as well as to healthy comparison subjects (N=177). The presence of specific and generalized cognitive deficits was examined.
The schizophrenia group presented widespread neuropsychological impairments and performed significantly worse than healthy comparison subjects on most neuropsychological measures. Patients with other psychotic disorders and depressive psychosis also demonstrated widespread impairments. Deficits in patients with bipolar disorder or mania were less pervasive but evident in performance scores on verbal memory and fluency tests. Differences between the four patient groups and healthy comparison subjects and among the patient groups were attenuated after controlling for differences in general cognitive ability (IQ).
Early in their course, cognitive deficits are present in all psychotic disorders but are most severe and pervasive in schizophrenia and least pervasive in bipolar disorder and mania.
Item Type
ArticleLanguage
enISSN
1535-7228ae974a485f413a2113503eed53cd6c53
10.1176/appi.ajp.2009.09010118
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