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dc.contributor.authorFisher, H L
dc.contributor.authorJones, P B
dc.contributor.authorFearon, P
dc.contributor.authorCraig, T K
dc.contributor.authorDazzan, P
dc.contributor.authorMorgan, K
dc.contributor.authorHutchinson, G
dc.contributor.authorDoody, G A
dc.contributor.authorMcGuffin, P
dc.contributor.authorLeff, J
dc.contributor.authorMurray, R M
dc.contributor.authorMorgan, C
dc.date.accessioned2011-04-27T10:39:31Z
dc.date.available2011-04-27T10:39:31Z
dc.date.issued2010-12
dc.identifier.citationThe varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. 2010, 40 (12):1967-78 Psychol Meden
dc.identifier.issn1469-8978
dc.identifier.pmid20178679
dc.identifier.doi10.1017/S0033291710000231
dc.identifier.urihttp://hdl.handle.net/10147/128741
dc.description.abstractChildhood adversity has been associated with onset of psychosis in adulthood but these studies have used only general definitions of this environmental risk indicator. Therefore, we sought to explore the prevalence of more specific adverse childhood experiences amongst those with and without psychotic disorders using detailed assessments in a large epidemiological case-control sample (AESOP).
dc.description.abstractData were collected on 182 first-presentation psychosis cases and 246 geographically matched controls in two UK centres. Information relating to the timing and frequency of exposure to different types of childhood adversity (neglect, antipathy, physical and sexual abuse, local authority care, disrupted living arrangements and lack of supportive figure) was obtained using the Childhood Experience of Care and Abuse Questionnaire.
dc.description.abstractPsychosis cases were three times more likely to report severe physical abuse from the mother that commenced prior to 12 years of age, even after adjustment for other significant forms of adversity and demographic confounders. A non-significant trend was also evident for greater prevalence of reported severe maternal antipathy amongst those with psychosis. Associations with maternal neglect and childhood sexual abuse disappeared after adjusting for maternal physical abuse and antipathy. Paternal maltreatment and other forms of adversity were not associated with psychosis nor was there evidence of a dose-response effect.
dc.description.abstractThese findings suggest that only specific adverse childhood experiences are associated with psychotic disorders and only in a minority of cases. If replicated, this greater precision will ensure that research into the mechanisms underlying the pathway from childhood adversity to psychosis is more fruitful.
dc.language.isoenen
dc.relation.urlDOI: 10.1017/S0033291710000231en
dc.subject.meshAdult
dc.subject.meshCase-Control Studies
dc.subject.meshChild
dc.subject.meshChild Abuse
dc.subject.meshFemale
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMother-Child Relations
dc.subject.meshPrevalence
dc.subject.meshPsychotic Disorders
dc.titleThe varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder.en
dc.typeArticleen
dc.contributor.departmentInstitute of Psychiatry, King's College London, UK. helen.fisher@iop.kcl.ac.uken
dc.identifier.journalPsychological medicineen
dc.description.provinceLeinster
refterms.dateFOA2024-01-09T11:43:45Z
html.description.abstractChildhood adversity has been associated with onset of psychosis in adulthood but these studies have used only general definitions of this environmental risk indicator. Therefore, we sought to explore the prevalence of more specific adverse childhood experiences amongst those with and without psychotic disorders using detailed assessments in a large epidemiological case-control sample (AESOP).
html.description.abstractData were collected on 182 first-presentation psychosis cases and 246 geographically matched controls in two UK centres. Information relating to the timing and frequency of exposure to different types of childhood adversity (neglect, antipathy, physical and sexual abuse, local authority care, disrupted living arrangements and lack of supportive figure) was obtained using the Childhood Experience of Care and Abuse Questionnaire.
html.description.abstractPsychosis cases were three times more likely to report severe physical abuse from the mother that commenced prior to 12 years of age, even after adjustment for other significant forms of adversity and demographic confounders. A non-significant trend was also evident for greater prevalence of reported severe maternal antipathy amongst those with psychosis. Associations with maternal neglect and childhood sexual abuse disappeared after adjusting for maternal physical abuse and antipathy. Paternal maltreatment and other forms of adversity were not associated with psychosis nor was there evidence of a dose-response effect.
html.description.abstractThese findings suggest that only specific adverse childhood experiences are associated with psychotic disorders and only in a minority of cases. If replicated, this greater precision will ensure that research into the mechanisms underlying the pathway from childhood adversity to psychosis is more fruitful.


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