• Measuring consistency of autobiographical memory recall in depression.

      Semkovska, Maria; Noone, Martha; Carton, Mary; McLoughlin, Declan M; Department of Psychiatry, Trinity College, Dublin, Ireland. semkovsm@tcd.ie (2012-05-15)
      Autobiographical amnesia assessments in depression need to account for normal changes in consistency over time, contribution of mood and type of memories measured. We report herein validation studies of the Columbia Autobiographical Memory Interview - Short Form (CAMI-SF), exclusively used in depressed patients receiving electroconvulsive therapy (ECT) but without previous published report of normative data. The CAMI-SF was administered twice with a 6-month interval to 44 healthy volunteers to obtain normative data for retrieval consistency of its Semantic, Episodic-Extended and Episodic-Specific components and assess their reliability and validity. Healthy volunteers showed significant large decreases in retrieval consistency on all components. The Semantic and Episodic-Specific components demonstrated substantial construct validity. We then assessed CAMI-SF retrieval consistencies over a 2-month interval in 30 severely depressed patients never treated with ECT compared with healthy controls (n=19). On initial assessment, depressed patients produced less episodic-specific memories than controls. Both groups showed equivalent amounts of consistency loss over a 2-month interval on all components. At reassessment, only patients with persisting depressive symptoms were distinguishable from controls on episodic-specific memories retrieved. Research quantifying retrograde amnesia following ECT for depression needs to control for normal loss in consistency over time and contribution of persisting depressive symptoms.
    • Mental health matters

      St Patrick's University Hospital (St Patrick's University Hospital, 2008-12-02)
    • Mental health matters

      St Patrick's University Hospital (St Patrick's University Hospital, 2008-02-12)
    • Mental health services: the way forward: the perspectives of young people and parents

      Buckley, Sarah; Gavin, Blainid; Noctor, Colman; Devitt, Catherine; Guerin, Suzanne; The Way Forward Project Team (St Patrick's University Hospital, 2012-09)
    • Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study.

      Eranti, Savithasri V; Mogg, Andrew J; Pluck, Graham C; Landau, Sabine; McLoughlin, Declan M; King's College London, Institute of Psychiatry, London, UK. (2009-02)
      Methohexitone has been the most widely used anaesthetic for electroconvulsive therapy (ECT). However, recent scarcity and erratic availability has led to use of other anaesthetics with differing effects upon ECT. We compared treatment parameters and response to ECT in patients anaesthetised with different anaesthetics in a routine clinical setting.
    • Migration and psychosis

      Fearon, P; St. Patrick's University Hospital, Dublin (2009)
    • Mobile phone text message interventions in psychiatry - what are the possibilities?

      I.O. Agyapong, Vincent; K. Farren, Conor; M. McLoughlin, Declan (2011-02)
    • Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.

      Yates, Darran M; Manser, Catherine; De Vos, Kurt J; Shaw, Christopher E; McLoughlin, Declan M; Miller, Christopher C J; MRC Centre for Neurodegeneration Research, Department of Neuroscience P037, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE58AF, UK. (2009-04)
      Neurofilaments are the intermediate filaments of neurons and are synthesised in neuronal cell bodies and then transported through axons. Neurofilament light chain (NFL) is a principal component of neurofilaments, and phosphorylation of NFL head domain is believed to regulate the assembly of neurofilaments. However, the role that NFL phosphorylation has on transport of neurofilaments is poorly understood. To address this issue, we monitored axonal transport of phosphorylation mutants of NFL. We mutated four known phosphorylation sites in NFL head domain to either preclude phosphorylation, or mimic permanent phosphorylation. Mutation to preclude phosphorylation had no effect on transport but mutation of three sites to mimic permanent phosphorylation inhibited transport. Mutation of all four sites together to mimic permanent phosphorylation proved especially potent at inhibiting transport and also disrupted neurofilament assembly. Our results suggest that NFL head domain phosphorylation is a regulator of neurofilament axonal transport.
    • Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis.

      Semkovska, Maria; McLoughlin, Declan M; Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, St. Patrick's University Hospital, Ireland. (2010-09-15)
      Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression, but is limited by cognitive side effects. However, research on their persistence, severity, and pattern is inconsistent. We aimed to quantify ECT-associated cognitive changes, specify their pattern, and determine progression.
    • Overcoming alcohol abuse: a 28 day guide

      Farren, C; St. Patrick's University Hospital, Dublin (Blackhall Press, 2011-02)
    • Practical administration of ECT

      Dunne, R.; McLoughlin, D.M.; St. Patrick's University Hospital, Dublin (Royal College of Psychiatrists, 2010)
    • Predictive factors for relapse after an integrated inpatient treatment programme for unipolar depressed and bipolar alcoholics.

      Farren, Conor K; McElroy, Sharon; Department of Psychiatry, St. Patrick’s Hospital and Trinity College Dublin, James Street, Dublin 8, Ireland. cfarren@stpatsmail.com (2011-04-27)
      The aim of this study was to examine prospectively examined predictors of relapse in alcohol dependence with comorbid affective disorder.
    • The prevalence, diagnostic significance and demographic characteristics of Schneiderian first-rank symptoms in an epidemiological sample of first-episode psychoses.

      Ihara, Kazushige; Morgan, Craig; Fearon, Paul; Dazzan, Paola; Demjaha, Arsime; Lloyd, Tuhina; Kirkbride, James B; Hayhurst, Hazel; Murray, Robin M; Jones, Peter B; et al. (2009)
      The diagnostic significance of first-rank symptoms (FRSs) remains uncertain. Ethnic differences in FRSs may account for high rates of schizophrenia in minority groups. This study aims to examine the prevalence of FRSs in an epidemiological sample of first-episode psychoses stratified by relevant demographic variables. SAMPLING AND METHOD: We identified everyone aged 16-64 presenting with their first psychosis over 2 years in 3 UK centres.
    • Promoter characterization and genomic organization of the human X11β gene APBA2.

      Hao, Yan; Chai, Ka-Ho; McLoughlin, Declan M; Chan, Ho Yin Edwin; Lau, Kwok-Fai; Biochemistry Program, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. (2012-02-15)
      Overexpression of neuronal adaptor protein X11β has been shown to decrease the production of amyloid-β, a toxic peptide deposited in Alzheimer's disease brains. Therefore, manipulation of the X11β level may represent a potential therapeutic strategy for Alzheimer's disease. As X11β expression can be regulated at the transcription level, we determined the genomic organization and the promoter of the human X11β gene, amyloid β A4 precursor protein-binding family A member 2 (APBA2). By RNA ligase-mediated rapid amplification of cDNA ends, a single APBA2 transcription start site and the complete sequence of exon 1 were identified. The APBA2 promoter was located upstream of exon 1 and was more active in neurons. The core promoter contains several CpG dinucleotides, and was strongly suppressed by DNA methylation. In addition, mutagenesis analysis revealed a putative Pax5-binding site within the promoter. Together, APBA2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and Pax5.
    • Promoting psychiatry as a career option for Ghanaian medical students through a public-speaking competition.

      Agyapong, Vincent Israel Opoku; McLoughlin, Declan; Department of Psychiatry, University of Dublin, St Patrick’s University Hospital, Dublin, Ireland. israelhans@hotmail.com (2012-05-01)
      Authors assessed the impact of a public-speaking competition on the level of interest in psychiatry of Ghanaian medical students.
    • Regional variation in electroconvulsive therapy use

      Dunne, R; McLoughlin, DM (Irish Medical Journal, 2011-03)
    • Regional variation in electroconvulsive therapy use.

      Dunne, R; McLoughlin, D M; Department of Psychiatry, Trinity College, St. Patrick's University Hospital, Dublin. ross.dunne@tcd.ie (2011-03)
      Although electroconvulsive therapy (ECT) is the most powerful treatment for depression, substantial variability in use has been described in Ireland. The Mental Health Commission collects usage data from approved centres but does not include home addresses or independent sector patients. Therefore, estimates of regional variation cannot be accurate, e.g. 145 (35% of total) independent sector patients were omitted from their 2008 analysis. When public and independent sector patients are combined inter-regional variation for 2008 is more than halved (chi-squared decreased from 83 to 30), with Western region contributing most to variation (chi-squared = 43). Ratio of ECT programmes to depressed admissions correlated negatively with rate for depressed admissions (r = -0.53, p = 0.01), while depressed admission numbers correlated with acute beds per area (r = 0.68, p = 0.001). Regional variation in ECT is less than previously reported; service factors probably account for much of this with smaller centres admitting severely ill patients more likely to require ECT.
    • Reliability and Comparability of Psychosis Patients' Retrospective Reports of Childhood Abuse

      Fisher, H. L.; Craig, T. K.; Fearon, P.; Morgan, K.; Dazzan, P.; Lappin, J.; Hutchinson, G.; Doody, G. A.; Jones, P. B.; McGuffin, P.; et al. (2009-09-23)
    • Residential mobility among individuals with severe mental illness: cohort study of UK700 participants.

      Tulloch, Alex D; Fearon, Paul; Fahy, Tom; David, Anthony; Department of Psychiatry, Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK. a.tulloch@iop.kcl.ac.uk (2010-08)
      There is limited research concerning residential mobility among people with severe mental illness.
    • Residential mobility among patients admitted to acute psychiatric wards

      Tulloch, Alex D.; Fearon, Paul; David, Anthony S. (2011)