• An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.

      Tracy, D K; O'Daly, O; Joyce, D W; Michalopoulou, P G; Basit, B B; Dhillon, G; McLoughlin, D M; Shergill, S S; CSI Lab, Department of Psychological Medicine, The Institute of Psychiatry, King's College London, UK. d.tracy@iop.kcl.ac.uk (2010-01)
      Auditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.