Insight, grey matter and cognitive function in first-onset psychosis.
dc.contributor.author | Morgan, Kevin D | |
dc.contributor.author | Dazzan, Paola | |
dc.contributor.author | Morgan, Craig | |
dc.contributor.author | Lappin, Julia | |
dc.contributor.author | Hutchinson, Gerard | |
dc.contributor.author | Suckling, John | |
dc.contributor.author | Fearon, Paul | |
dc.contributor.author | Jones, Peter B | |
dc.contributor.author | Leff, Julian | |
dc.contributor.author | Murray, Robin M | |
dc.contributor.author | David, Anthony S | |
dc.date.accessioned | 2011-04-27T10:38:05Z | |
dc.date.available | 2011-04-27T10:38:05Z | |
dc.date.issued | 2010-08 | |
dc.identifier.citation | Insight, grey matter and cognitive function in first-onset psychosis. 2010, 197:141-8 Br J Psychiatry | en |
dc.identifier.issn | 1472-1465 | |
dc.identifier.pmid | 20679268 | |
dc.identifier.doi | 10.1192/bjp.bp.109.070888 | |
dc.identifier.uri | http://hdl.handle.net/10147/128727 | |
dc.description.abstract | Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. | |
dc.description.abstract | Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. | |
dc.description.abstract | Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. | |
dc.description.abstract | The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. | |
dc.description.abstract | The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis. | |
dc.language.iso | en | en |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Brain Mapping | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Cerebral Ventricles | |
dc.subject.mesh | Cognition | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gyrus Cinguli | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Image Processing, Computer-Assisted | |
dc.subject.mesh | Magnetic Resonance Imaging | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Neuropsychological Tests | |
dc.subject.mesh | Schizophrenia | |
dc.subject.mesh | Schizophrenic Psychology | |
dc.subject.mesh | Young Adult | |
dc.title | Insight, grey matter and cognitive function in first-onset psychosis. | en |
dc.type | Article | en |
dc.contributor.department | Department of Psychology, University of Westminster, 309 Regent Street, London W1B 2UW, UK. k.d.morgan@westminster.ac.uk | en |
dc.identifier.journal | The British journal of psychiatry : the journal of mental science | en |
dc.description.province | Leinster | |
html.description.abstract | Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. | |
html.description.abstract | Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. | |
html.description.abstract | Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. | |
html.description.abstract | The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. | |
html.description.abstract | The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis. |