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dc.contributor.authorMorgan, Kevin D
dc.contributor.authorDazzan, Paola
dc.contributor.authorMorgan, Craig
dc.contributor.authorLappin, Julia
dc.contributor.authorHutchinson, Gerard
dc.contributor.authorSuckling, John
dc.contributor.authorFearon, Paul
dc.contributor.authorJones, Peter B
dc.contributor.authorLeff, Julian
dc.contributor.authorMurray, Robin M
dc.contributor.authorDavid, Anthony S
dc.date.accessioned2011-04-27T10:38:05Z
dc.date.available2011-04-27T10:38:05Z
dc.date.issued2010-08
dc.identifier.citationInsight, grey matter and cognitive function in first-onset psychosis. 2010, 197:141-8 Br J Psychiatryen
dc.identifier.issn1472-1465
dc.identifier.pmid20679268
dc.identifier.doi10.1192/bjp.bp.109.070888
dc.identifier.urihttp://hdl.handle.net/10147/128727
dc.description.abstractSeveral studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures.
dc.description.abstractFocusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.
dc.description.abstractVoxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.
dc.description.abstractThe principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.
dc.description.abstractThe cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBrain
dc.subject.meshBrain Mapping
dc.subject.meshCase-Control Studies
dc.subject.meshCerebral Ventricles
dc.subject.meshCognition
dc.subject.meshFemale
dc.subject.meshGyrus Cinguli
dc.subject.meshHumans
dc.subject.meshImage Processing, Computer-Assisted
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeuropsychological Tests
dc.subject.meshSchizophrenia
dc.subject.meshSchizophrenic Psychology
dc.subject.meshYoung Adult
dc.titleInsight, grey matter and cognitive function in first-onset psychosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychology, University of Westminster, 309 Regent Street, London W1B 2UW, UK. k.d.morgan@westminster.ac.uken
dc.identifier.journalThe British journal of psychiatry : the journal of mental scienceen
dc.description.provinceLeinster
html.description.abstractSeveral studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures.
html.description.abstractFocusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.
html.description.abstractVoxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.
html.description.abstractThe principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.
html.description.abstractThe cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.


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