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    Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study.

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    Authors
    Eranti, Savithasri V
    Mogg, Andrew J
    Pluck, Graham C
    Landau, Sabine
    McLoughlin, Declan M
    Affiliation
    King's College London, Institute of Psychiatry, London, UK.
    Issue Date
    2009-02
    MeSH
    Aged
    Anesthetics, Intravenous
    Depressive Disorder, Major
    Electroconvulsive Therapy
    Etomidate
    Female
    Humans
    Male
    Methohexital
    Middle Aged
    Propofol
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    Citation
    Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study. 2009, 113 (1-2):165-71 J Affect Disord
    Journal
    Journal of affective disorders
    URI
    http://hdl.handle.net/10147/128720
    DOI
    10.1016/j.jad.2008.03.004
    PubMed ID
    18439686
    Additional Links
    doi:10.1016/j.jad.2008.03.004
    Abstract
    Methohexitone has been the most widely used anaesthetic for electroconvulsive therapy (ECT). However, recent scarcity and erratic availability has led to use of other anaesthetics with differing effects upon ECT. We compared treatment parameters and response to ECT in patients anaesthetised with different anaesthetics in a routine clinical setting.
    This was a naturalistic retrospective casenote analysis of 81 consecutive courses of ECT (total 659 treatments) for major depression.
    Three anaesthetics were compared: methohexitone (n=34), propofol (n=13) and etomidate (n=34). Mean seizure duration was lowest (p<0.0001) for propofol. However, mean stimulus charge was highest in the propofol group (p<0.0001) who required a greater increase in stimulus charge during the course of treatment and also experienced a greater proportion of failed seizures (
    This was a retrospective casenote study, in which patients were not randomised to anaesthetic and standardised outcome measures were not used. The small sample size in the propofol group may have reduced the power of the study to demonstrate other differences between propofol and the other anaesthetic groups. A formal economic analysis was not performed.
    Individual anaesthetics differentially influence seizure duration and stimulus charge but final response to ECT appears not to be adversely affected.
    Language
    en
    ISSN
    0165-0327
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jad.2008.03.004
    Scopus Count
    Collections
    St. Patrick's University Hospital

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