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dc.contributor.authorTracy, D K
dc.contributor.authorO'Daly, O
dc.contributor.authorJoyce, D W
dc.contributor.authorMichalopoulou, P G
dc.contributor.authorBasit, B B
dc.contributor.authorDhillon, G
dc.contributor.authorMcLoughlin, D M
dc.contributor.authorShergill, S S
dc.date.accessioned2011-04-27T09:17:28Z
dc.date.available2011-04-27T09:17:28Z
dc.date.issued2010-01
dc.identifier.citationAn evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers. 2010, 48 (1):270-7 Neuropsychologiaen
dc.identifier.issn1873-3514
dc.identifier.pmid19769994
dc.identifier.doi10.1016/j.neuropsychologia.2009.09.013
dc.identifier.urihttp://hdl.handle.net/10147/128716
dc.description.abstractAuditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.
dc.description.abstractSingle-blind placebo controlled fMRI study of 24 healthy volunteers undertaking an auditory temporoparietal activation task, who received either right temporoparietal rTMS or sham RTMS.
dc.description.abstractThe main effect of group was bilateral inferior parietal deactivation following real rTMS. An interaction of group and task type showed deactivation during real rTMS in the right superior temporal gyrus (STG), left thalamus, left postcentral gyrus and cerebellum. However, the left parietal lobe showed an increase in activation following right sided real rTMS, but this increase was specific to a non-linguistic, tone-sequence task.
dc.description.abstractrTMS does cause local inhibitory effects, not only in the underlying region of application, but also in functionally connected cortical regions. However, there is also a related, task dependent, increase in activation within selected cortical areas in the contralateral hemisphere; these are likely to reflect compensatory mechanisms, and such cortical activation may in some cases contribute to, or retard, some of the therapeutic effects seen with rTMS.
dc.language.isoenen
dc.relation.urldoi:10.1016/j.neuropsychologia.2009.09.013en
dc.subject.meshAcoustic Stimulation
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnalysis of Variance
dc.subject.meshBrain
dc.subject.meshBrain Mapping
dc.subject.meshEvoked Potentials, Auditory
dc.subject.meshFemale
dc.subject.meshHallucinations
dc.subject.meshHumans
dc.subject.meshImage Processing, Computer-Assisted
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOxygen
dc.subject.meshSingle-Blind Method
dc.subject.meshTranscranial Magnetic Stimulation
dc.subject.meshYoung Adult
dc.titleAn evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.en
dc.typeArticleen
dc.contributor.departmentCSI Lab, Department of Psychological Medicine, The Institute of Psychiatry, King's College London, UK. d.tracy@iop.kcl.ac.uken
dc.identifier.journalNeuropsychologiaen
dc.description.provinceLeinster
html.description.abstractAuditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.
html.description.abstractSingle-blind placebo controlled fMRI study of 24 healthy volunteers undertaking an auditory temporoparietal activation task, who received either right temporoparietal rTMS or sham RTMS.
html.description.abstractThe main effect of group was bilateral inferior parietal deactivation following real rTMS. An interaction of group and task type showed deactivation during real rTMS in the right superior temporal gyrus (STG), left thalamus, left postcentral gyrus and cerebellum. However, the left parietal lobe showed an increase in activation following right sided real rTMS, but this increase was specific to a non-linguistic, tone-sequence task.
html.description.abstractrTMS does cause local inhibitory effects, not only in the underlying region of application, but also in functionally connected cortical regions. However, there is also a related, task dependent, increase in activation within selected cortical areas in the contralateral hemisphere; these are likely to reflect compensatory mechanisms, and such cortical activation may in some cases contribute to, or retard, some of the therapeutic effects seen with rTMS.


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