• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. Patrick's University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. Patrick's University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5001
    UlsterS
    5001
    Connacht
    1673
    Munster
    55
    Leinster
    456

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    Tracy, D K
    O'Daly, O
    Joyce, D W
    Michalopoulou, P G
    Basit, B B
    Dhillon, G
    McLoughlin, D M
    Shergill, S S
    Affiliation
    CSI Lab, Department of Psychological Medicine, The Institute of Psychiatry, King's College London, UK. d.tracy@iop.kcl.ac.uk
    Issue Date
    2010-01
    MeSH
    Acoustic Stimulation
    Adolescent
    Adult
    Analysis of Variance
    Brain
    Brain Mapping
    Evoked Potentials, Auditory
    Female
    Hallucinations
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Oxygen
    Single-Blind Method
    Transcranial Magnetic Stimulation
    Young Adult
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers. 2010, 48 (1):270-7 Neuropsychologia
    Journal
    Neuropsychologia
    URI
    http://hdl.handle.net/10147/128716
    DOI
    10.1016/j.neuropsychologia.2009.09.013
    PubMed ID
    19769994
    Additional Links
    doi:10.1016/j.neuropsychologia.2009.09.013
    Abstract
    Auditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal cortices and are refractory to pharmacological and psychological treatment in approximately 25% of patients. Low frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex has been demonstrated to be effective in reducing AVH in some patients, although results have varied. The cortical mechanism by which rTMS exerts its effects remain unknown, although data from the motor system is suggestive of a local cortical inhibitory effect. We explored neuroimaging differences in healthy volunteers between application of a clinically utilized rTMS protocol and a sham rTMS equivalent when undertaking a prosodic auditory task.
    Single-blind placebo controlled fMRI study of 24 healthy volunteers undertaking an auditory temporoparietal activation task, who received either right temporoparietal rTMS or sham RTMS.
    The main effect of group was bilateral inferior parietal deactivation following real rTMS. An interaction of group and task type showed deactivation during real rTMS in the right superior temporal gyrus (STG), left thalamus, left postcentral gyrus and cerebellum. However, the left parietal lobe showed an increase in activation following right sided real rTMS, but this increase was specific to a non-linguistic, tone-sequence task.
    rTMS does cause local inhibitory effects, not only in the underlying region of application, but also in functionally connected cortical regions. However, there is also a related, task dependent, increase in activation within selected cortical areas in the contralateral hemisphere; these are likely to reflect compensatory mechanisms, and such cortical activation may in some cases contribute to, or retard, some of the therapeutic effects seen with rTMS.
    Item Type
    Article
    Language
    en
    ISSN
    1873-3514
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuropsychologia.2009.09.013
    Scopus Count
    Collections
    St. Patrick's University Hospital

    entitlement

    Related articles

    • Functional connectivity of the temporo-parietal region in schizophrenia: effects of rTMS treatment of auditory hallucinations.
    • Authors: Vercammen A, Knegtering H, Liemburg EJ, den Boer JA, Aleman A
    • Issue date: 2010 Aug
    • Combining functional neuroimaging with off-line brain stimulation: modulation of task-related activity in language areas.
    • Authors: Andoh J, Paus T
    • Issue date: 2011 Feb
    • Effects of low frequency rTMS treatment on brain networks for inner speech in patients with schizophrenia and auditory verbal hallucinations.
    • Authors: Bais L, Liemburg E, Vercammen A, Bruggeman R, Knegtering H, Aleman A
    • Issue date: 2017 Aug 1
    • Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial.
    • Authors: Vercammen A, Knegtering H, Bruggeman R, Westenbroek HM, Jenner JA, Slooff CJ, Wunderink L, Aleman A
    • Issue date: 2009 Oct
    • Theta Burst Transcranial Magnetic Stimulation for Auditory Verbal Hallucinations: Negative Findings From a Double-Blind-Randomized Trial.
    • Authors: Koops S, van Dellen E, Schutte MJ, Nieuwdorp W, Neggers SF, Sommer IE
    • Issue date: 2016 Jan
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.