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dc.contributor.authorLau, Kwok-Fai
dc.contributor.authorPerkinton, Michael S
dc.contributor.authorRodriguez, Lilia
dc.contributor.authorMcLoughlin, Declan M
dc.contributor.authorMiller, Christopher C J
dc.date.accessioned2011-04-27T09:06:48Z
dc.date.available2011-04-27T09:06:48Z
dc.date.issued2010-08-04
dc.identifier.citationAn X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. 2010, 21 (11):761-6 Neuroreporten
dc.identifier.issn1473-558X
dc.identifier.pmid20531236
dc.identifier.doi10.1097/WNR.0b013e32833bfca0
dc.identifier.urihttp://hdl.handle.net/10147/128714
dc.description.abstractX11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896363/?tool=pubmeden
dc.subject.meshAdaptor Proteins, Signal Transducing
dc.subject.meshAlzheimer Disease
dc.subject.meshAnimals
dc.subject.meshBlotting, Northern
dc.subject.meshBrain
dc.subject.meshCHO Cells
dc.subject.meshCricetinae
dc.subject.meshCricetulus
dc.subject.meshGene Expression Regulation
dc.subject.meshGlycogen Synthase Kinase 3
dc.subject.meshHumans
dc.subject.meshMultiprotein Complexes
dc.subject.meshNerve Tissue Proteins
dc.subject.meshPromoter Regions, Genetic
dc.subject.meshRats
dc.subject.meshTranscription Factors
dc.subject.meshTranscription, Genetic
dc.subject.meshTransfection
dc.subject.meshTwo-Hybrid System Techniques
dc.titleAn X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. kflau@cuhk.edu.hken
dc.identifier.journalNeuroreporten
dc.description.provinceLeinster
refterms.dateFOA2018-08-22T12:12:47Z
html.description.abstractX11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.


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