• The way forward for the refractory asthmatic

      Kooblall, M; Moloney, E; Lane, SJ (Irish Medical Journal, 2015-07)
      Ireland has the fourth highest prevalence of asthma in the world. 7.1% of 18+ population and 18.9% of 13-15 year olds have asthma. 38.5% of 13-15 year olds reported wheezing. More than 1 person a week dies from asthma and 29% of asthma patients miss school or work. 1 Despite very safe and effective treatment 5-10% of patients with bronchial asthma do not respond well to their treatment. This group of patients are labelled as refractory asthmatics. Besides compliance, presence of psychogenic and trigger factors and comorbid illness, steroid insensitiveness or resistance may play a significant role in the poorly controlled/responding asthmatics. Type I Steroid resistance is due to lack of binding affinity of steroids to glucocorticoid receptors and may respond to higher doses of steroids while type II steroid resistance is because of reduced number of cells with glucocorticoid receptors, which is very rare and do not respond to even higher doses of systemic steroids and these cases require alternative/novel therapies. 2
    • What is my risk of developing cardiovascular disease?

      Graham, Ian M; Cooney, Marie-Therese; Dudina, Alexandra; Squarta, Sophie; Trinity College and Department of Cardiology, The Adelaide and Meath Hospital, Incorporating National Childrens' Hospital Tallaght, Dublin, Ireland., ian.graham@amnch.ie (2012-02-01)
    • What is the place of new risk markers in the prediction of cardiovascular disease

      DeBacker, G; Cooney, MT; Graham, IM (European Journal Cardiovascular Prevention Rehabilitation, 2011)
    • Where does Pelvic and Acetabular Fracture Treatment fit into the Newly Proposed Major Trauma Model in Ireland?

      Fenelon, C; Murphy, E.P; O’Daly, B.J; Leonard, M (Irish Medical Journal, 2019-04)
      Major trauma continues to be the biggest cause of death in people aged between 5 and 45 years of age. Suboptimal trauma management results in greater ongoing costs to patients, hospitals and society. Trauma networks in the United States, Australia and more recently the United Kingdom have proven successful in significantly reducing morbidity and mortality. In the UK, analysis by the Trauma Audit Research Network (TARN) has shown that a major trauma patient has a 19% increase in the odds of survival following major trauma since its introduction in 2012. No integrated trauma network yet exists in Ireland but a recent report “A Trauma System for Ireland” published in January of 2018 outlined plans of how such a trauma network would be introduced. The report called for the introduction of two regional trauma networks, a central and south network, with one major trauma centre for each. However, the report made no mention of where the treatment of pelvic and acetabular fractures fell within it.
    • Whole-Body MRI versus PET in assessment of multiple myeloma disease activity.

      Shortt, Conor P; Gleeson, Tadhg G; Breen, Karen A; McHugh, John; O'Connell, Martin J; O'Gorman, Peter J; Eustace, Stephen J; Department of Radiology and Diagnostic Imaging, Mater Misericordiae University Hospital, Dublin, Ireland. (AJR. American journal of roentgenology, 2009-04)
      The purpose of this study was to compare FDG PET; whole-body MRI; and the reference standard, bone marrow aspiration and biopsy, to determine the best imaging technique for assessment of disease activity in multiple myeloma.
    • The worrying modern scenario of benign pathology after nephrectomy for presumed renal cancer

      Inder, SM; Smyth, L; Davis, NF; Thornhill, J (Irish Medical Journal, 2016-01)
      The detection of incidental renal tumours has dramatically increased over the last twenty years as a result of widespread ultrasound and CT scanning for various other conditions. Renal cancer is now an incidental diagnosis in over 50% of cases 1 . Survival rates have dramatically improved as a result of early surgical intervention (radical or partial nephrectomy) 2 . However, despite advances in radiology, benign renal lesions may be indeterminate from renal cancer. We report our incidence of patients undergoing nephrectomy for clinically diagnosed renal cancer but with subsequent benign pathology.
    • X inactivation in females with X-linked Charcot-Marie-Tooth disease.

      Murphy, Sinéad M; Ovens, Richard; Polke, James; Siskind, Carly E; Laurà, Matilde; Bull, Karen; Ramdharry, Gita; Houlden, Henry; Murphy, Raymond P J; Shy, Michael E; et al. (Neuromuscular disorders : NMD, 2012-07)
      X-linked Charcot-Marie-Tooth disease (CMT1X) is the second most common inherited neuropathy, caused by mutations in gap junction beta-1 (GJB1). Males have a uniformly moderately severe phenotype while females have a variable phenotype, suggested to be due to X inactivation. We aimed to assess X inactivation pattern in females with CMT1X and correlate this with phenotype using the CMT examination score to determine whether the X inactivation pattern accounted for the variable phenotype in females with CMT1X. We determined X inactivation pattern in 67 females with CMT1X and 24 controls using the androgen receptor assay. We were able to determine which X chromosome carried the GJB1 mutation in 30 females. There was no difference in X inactivation pattern between patients and controls. In addition, there was no correlation between X inactivation pattern in blood and phenotype. A possible explanation for these findings is that the X inactivation pattern in Schwann cells rather than in blood may explain the variable phenotype in females with CMT1X.
    • Young, Male and Feeling Suicidal in Ireland: Is Help or Harm Just One Click Away?

      Gilhooley, J; Bolger, M; Charles, A; Cleary, E; Lane, A; Malone, K (Irish Medical Journal, 2015-12)
      Reports suggest an association between internet use and the elevated risk of suicide and self harm. 1 This study examined the resources a suicidal person might find when searching the internet ’front page’ for help. Voluntary suicide help websites accounted for 7/12 front page hits. The National Suicide Research Foundation (NSRF) and the National Office for Suicide Prevention (NOSP), a blog and a newspaper article made up the remainder. Sites were difficult to navigate and highly variable in content. Phone credit was required in many cases in order to contact helplines; opening hours and locations were limited. Most statutory websites referred help-seekers to the voluntary sector, mainly the Samaritans. Information on fundraising and volunteering competed with other sources of help. Of concern, the front page also included links to methods to complete suicide. Irish professional medical bodies offered very limited advice. Our findings suggest that online information is variable and potentially harmful. There is an opportunity for all agencies and providers to generate a co-ordinated internet front page tailored for at-risk groups
    • 'YouTube': a useful tool for reminiscence therapy in dementia?

      O'Rourke, Julia; Tobin, Fiona; O'Callaghan, Susan; Sowman, Rebecca; Collins, D R; Department of Speech & Language Therapy, Adelaide & Meath Hospital Tallaght, Dublin, Ireland. orourke.julia@gmail.com (2011-11)
    • YouTube: A useful tool for the older generation?

      Collins, DR; Sowman, R; Tobin, F; O'Rourke, J; Liston, R (Geriatric Medicine: Midlife & Beyond, 2010)
    • Zinc status in children with CF

      Roddy, M (2009)
      9th National Cystic Fibrosis Conference, Kilarney