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Thyroid disorders in girls with Turner syndrome and the influence of the underlying karyotype.The risk of developing thyroid dysfunction is higher in Turner syndrome (TS) than the general population 1,2 . In previous studies, the influence of karyotype 3 and thyroid autoantibodies 4 on thyroid disorder in patients with TS has been investigated. We therefore set out to determine the prevalence of thyroid dysfunction in Irish girls with TS. The impact of underlying karyotype and thyroid autoantibodies has also been examined. The presence of thyroid dysfunction was assessed by measuring serum thyroid-stimulating hormone (TSH), thyroxin (T4) and anti-thyroid peroxidase antibodies (TPO-Ab) values. The association between TPO-Ab values and thyroid dysfunction (hypothyroidism and hyperthyroidism) was also assessed.