• Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial.

      Ederle, Jörg; Bonati, Leo H; Dobson, Joanna; Featherstone, Roland L; Gaines, Peter A; Beard, Jonathan D; Venables, Graham S; Markus, Hugh S; Clifton, Andrew; Sandercock, Peter; et al. (Lancet neurology, 2009-10)
      Endovascular treatment (angioplasty with or without stenting) is an alternative to carotid endarterectomy for carotid artery stenosis but there are scarce long-term efficacy data showing that it prevents stroke. We therefore report the long-term results of the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS).
    • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector.

      Luo, Xiaoyan; Hall, Gentzon; Li, Songtao; Bird, Andrew; Lavin, Peter J; Winn, Michelle P; Kemper, Alex R; Brown, Talmage T; Koeberl, Dwight D; Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA. (2011-11)
      Glycogen storage disease type Ia (GSD-Ia) is caused by the deficiency of glucose-6-phosphatase (G6Pase). Long-term complications of GSD-Ia include life-threatening hypoglycemia and proteinuria progressing to renal failure. A double-stranded (ds) adeno-associated virus serotype 2 (AAV2) vector encoding human G6Pase was pseudotyped with four serotypes, AAV2, AAV7, AAV8, and AAV9, and we evaluated efficacy in 12-day-old G6pase (-/-) mice. Hypoglycemia during fasting (plasma glucose <100 mg/dl) was prevented for >6 months by the dsAAV2/7, dsAAV2/8, and dsAAV2/9 vectors. Prolonged fasting for 8 hours revealed normalization of blood glucose following dsAAV2/9 vector administration at the higher dose. The glycogen content of kidney was reduced by >65% with both the dsAAV2/7 and dsAAV2/9 vectors, and renal glycogen content was stably reduced between 7 and 12 months of age for the dsAAV2/9 vector-treated mice. Every vector-treated group had significantly reduced glycogen content in the liver, in comparison with untreated G6pase (-/-) mice. G6Pase was expressed in many renal epithelial cells of with the dsAAV2/9 vector for up to 12 months. Albuminuria and renal fibrosis were reduced by the dsAAV2/9 vector. Hepatorenal correction in G6pase (-/-) mice demonstrates the potential of AAV vectors for the correction of inherited diseases of metabolism.
    • Laparoscopic resection for low rectal cancer: evaluation of oncological efficacy.

      Moran, Diarmaid C; Kavanagh, Dara O; Nugent, Emmeline; Swan, Niall; Eguare, Emmanuel; O'Riordain, Diarmuid; Keane, Frank B V; Neary, Paul C; Division of Colorectal Surgery, Minimally Invasive Surgery, AMNCH, Tallaght, Dublin, 24, Ireland. morandiarmaid@gmail.com (International journal of colorectal disease, 2011-09)
      Laparoscopic resection of low rectal cancer poses significant technical difficulties for the surgeon. There is a lack of published follow-up data in relation to the surgical, oncological and survival outcomes in these patients.
    • Laparoscopic surgery for rectal cancer: a single-centre experience of 120 cases.

      Good, Daniel W; O'Riordan, James M; Moran, Diarmaid; Keane, Frank B; Eguare, Emmanuel; O'Riordain, Diarmuid S; Neary, Paul C; Minimally Invasive Surgical Unit, Division of Colorectal Surgery, Adelaide and Meath Incorporating the National Childrens Hospital, Tallaght, Dublin 24, Ireland. goodd@tcd.ie (International journal of colorectal disease, 2011-10)
      For colorectal surgeons, laparoscopic rectal cancer surgery poses a new challenge. The defence of the questionable oncological safety tempered by the impracticality of the long learning curve is rapidly fading. As a unit specialising in minimally invasive surgery, we have routinely undertaken rectal cancer surgery laparoscopically since 2005.
    • Large cell neuroendocrine carcinoma of the ampulla of Vater.

      Beggs, Rachel E; Kelly, Michael E; Eltayeb, Omer; Crotty, Paul; McDermott, Ray; Ridgway, Paul F; Department of Surgery, The Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital, Dublin, Ireland. (2012-09)
      Large cell neuroendocrine carcinomas of the ampulla of Vater are rare and confer a very poor prognosis despite aggressive therapy. There are few case reports of large cell neuroendocrine carcinomas of the ampulla of Vater in the literature and to date no studies have been done to establish optimal management. We describe a pooled case series from published reports of neuroendocrine carcinomas of the ampulla of Vater including a case which presented to our institution.
    • Long-term outcome of endovascular treatment versus medical care for carotid artery stenosis in patients not suitable for surgery and randomised in the Carotid and Vertebral Artery Transluminal Angioplasty study (CAVATAS).

      Ederle, Jörg; Featherstone, Roland L; Brown, Martin M; Stroke Research Group, UCL Institute of Neurology, London, UK. (Cerebrovascular diseases (Basel, Switzerland), 2009)
      Optimal treatment of carotid stenosis in patients not suitable for surgery is unclear. The Carotid and Vertebral Artery Transluminal Angioplasty study contained a trial comparing medical and endovascular treatment in patients not suitable for surgery.
    • Peritoneal dialysis in an ageing population: a 10-year experience.

      Smyth, Andrew; McCann, Evonne; Redahan, Lynn; Lambert, Barbara; Mellotte, George J; Wall, Catherine A; Department of Nephrology, Adelaide & Meath Hospital, Dublin 24, Tallaght, Ireland. andrewsmyth@physicians.ie (2012-02)
      Chronic kidney disease (CKD) is becoming increasingly prevalent and there are increasing numbers of older patients with advanced CKD. Peritoneal dialysis (PD) is a potential treatment. This study aims to compare PD outcomes in age-defined populations in the largest PD centre in the Republic of Ireland over 10 years.
    • Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia.

      Corrado, Domenico; Calkins, Hugh; Link, Mark S; Leoni, Loira; Favale, Stefano; Bevilacqua, Michela; Basso, Cristina; Ward, Deirdre; Boriani, Giuseppe; Ricci, Renato; et al. (Circulation, 2010-09-21)
      The role of implantable cardioverter-defibrillator (ICD) in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation (VF) or sustained ventricular tachycardia is an unsolved issue.
    • Short-term outcomes following laparoscopic resection for colon cancer.

      Kavanagh, Dara O; Gibson, David; Moran, Diarmaid C; Smith, Myles; O Donnell, Kate; Eguare, Emmanuel; Keane, Frank B V; O Riordain, Diarmaid S; Neary, Paul C; Division of Colorectal Surgery, Adelaide and Meath Incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland. dara_kav@hotmail.com (International journal of colorectal disease, 2011-03)
      Laparoscopic resection for colon cancer has been proven to have a similar oncological efficacy compared to open resection. Despite this, it is performed by a minority of colorectal surgeons. The aim of our study was to evaluate the short-term clinical, oncological and survival outcomes in all patients undergoing laparoscopic resection for colon cancer.