• Proteomic classification of breast cancer.

      Kamel, Dalia; Brady, Bernadette; Tabchy, Adel; Mills, Gordon B; Hennessy, Bryan; Department of Medical Oncology, Our Lady of Lourdes Hospital, Drogheda, Ireland. dsskamel@hotmail.com (2012-11)
      Being a significant health problem that affects patients in various age groups, breast cancer has been extensively studied to date. Recently, molecular breast cancer classification has advanced significantly with the availability of genomic profiling technologies. Proteomic technologies have also advanced from traditional protein assays including enzyme-linked immunosorbent assay, immunoblotting and immunohistochemistry to more comprehensive approaches including mass spectrometry and reverse phase protein lysate arrays (RPPA). The purpose of this manuscript is to review the current protein markers that influence breast cancer prediction and prognosis and to focus on novel advances in proteomic classification of breast cancer.
    • Referral patterns of patients with liver metastases due to colorectal cancer for resection.

      Al-Sahaf, O; Al-Azawi, Dhafir; Al-Khudairy, Ammar; Fauzi, Mohammad Z; El-Masry, Sherif; Gilen, Peter; Department of General Surgery, Our Lady of Lourdes Hospital, Drogheda, Co.,, Louth, Ireland. Usama_sahaf70@hotmail.com (2012-02-01)
      INTRODUCTION: Colorectal carcinoma accounts for 10% of cancer deaths in the Western World, with the liver being the most common site of distant metastases. Resection of liver metastases is the treatment of choice, with a 5-year survival rate of 35%. However, only 5-10% of patients are suitable for resection at presentation. AIMS: To examine the referral pattern of patients with liver metastases to a specialist hepatic unit for resection. METHODOLOGY: Retrospective review of patient's charts diagnosed with colorectal liver metastases over a 10-year period. RESULTS: One hundred nine (38 women, 71 men) patients with liver metastases were included, mean age 61 years; 79 and 30 patients had synchronous and metachronus metastases, respectively. Ten criteria for referral were identified; the referral rate was 8.25%, with a resection rate of 0.9%. Forty two percent of the patients had palliative chemotherapy; 42% had symptomatic treatment. CONCLUSION: This study highlights the advanced stage of colorectal cancer at presentation; in light of modern evidence-based, centre-oriented therapy of liver metastasis, we conclude that criteria of referral for resection should be based on the availability of treatment modalities.