Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link.

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Authors
Conroy, H
Mawhinney, L
Donnelly, S C
Affiliation
Conway Institute for Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.
Issue Date
2010-11
MeSH
Animals
Biological Markers
Cell Hypoxia
Disease Progression
Humans
Inflammation
Macrophage Migration-Inhibitory Factors
Mice
Neoplasms
Neovascularization, Pathologic

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Citation
Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link. 2010, 103 (11):831-6 QJM
Journal
QJM : monthly journal of the Association of Physicians
URI
http://hdl.handle.net/10147/128251
DOI
10.1093/qjmed/hcq148
PubMed ID
20805118
Abstract
Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.
Item Type
Article
Language
en
ISSN
1460-2393
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