Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link.
AffiliationConway Institute for Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.
Macrophage Migration-Inhibitory Factors
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CitationInflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link. 2010, 103 (11):831-6 QJM
JournalQJM : monthly journal of the Association of Physicians
AbstractMacrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.
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