Browsing St. James's Hospital by Subjects
Now showing items 1-1 of 1
Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.KB-8-5-11 cells are a drug-resistant cervical cell model that overexpresses ABCB1 (P-glycoprotein). KB-8-5-11 has become sensitive to non-ABCB1 substrate cisplatin. Understanding the mechanism of collateral sensitivity to cisplatin may lead to biomarker discovery for platinum sensitivity in patients with cancer.