• Impaired glucose metabolism in HIV-infected pregnant women: a retrospective analysis.

      Moore, Rebecca; Adler, Hugh; Jackson, Valerie; Lawless, Mairead; Byrne, Maria; Eogan, Maeve; Lambert, John S; Rotunda Hospital Dublin (2015-05-20)
      Metabolic complications including diabetes mellitus have been increasingly recognised in HIV-infected individuals since the introduction of antiretroviral therapy, particularly protease inhibitors (PIs). Pregnancy is also a risk factor for impaired glucose metabolism, and previous studies have given conflicting results regarding the contribution of PIs to impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) in pregnant HIV-infected women.
    • Platelet function in patients with a history of unexplained recurrent miscarriage who subsequently miscarry again.

      Dempsey, Mark Anthony; Flood, Karen; Burke, Naomi; Murray, Aoife; Cotter, Brian; Mullers, Sieglinde; Dicker, Patrick; Fletcher, Patricia; Geary, Michael; Kenny, Dermot; et al. (2015-05)
      This study was designed to evaluate platelet aggregation in pregnant women with a history of unexplained recurrent miscarriage (RM) and to compare platelet function in such patients who go on to have either another subsequent miscarriage or a successful pregnancy.
    • Relation between birth weight and weight and height at the age of 2 in children born preterm.

      Olson, Gayle; Weiner, Steven J; Rouse, Dwight J; Reddy, Uma M; Mercer, Brian M; Varner, Michael W; Leveno, Kenneth J; Iams, Jay D; Wapner, Ronald J; Ramin, Susan M; et al. (2015-05)
      The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight.
    • Neurodevelopmental outcome at seven years in term, acidotic newborns

      Diviney, M; Pinnamaneni, R; Murphy, JFA; Lynch, B; Rushe, H; Madigan, C; Geary, M; Foran, A (Irish Medical Journal, 2015-04)
      The objective was to follow up a cohort of acidotic full-term infants with or without hypoxic ischemic encephalopathy (HIE) and determine if at 7 years they displayed any neurodevelopmental delays. Children (n=44) were divided according to those with mild (n=25) or severe (n=19) acidosis and were then further subdivided into those with or without HIE. Participants were assessed using the Wechsler Intelligence Scale for Children (WISC-IVUK) and Achenbach Child Behaviour Checklist (CBCL). No differences in WISC-IVUK scores in children without HIE irrespective of the cord pH values were found. Children with HIE grade I scored significantly higher in perceptual reasoning than those with grade III (p<0.01). CBCL scores revealed no differences between groups. Findings suggest evidence of impairment at school-age that correlates with the degree of encephalopathy. Acidosis without the presence of clinical encephalopathy was associated with normal outcome.
    • The PORTO study and the importance of cerebroplacental ratio in fetal growth restriction.

      Morales-Roselló, José; Khalil, Asma; Perales-Marín, Alfredo; Malone, F D; Rotunda Hospital (2015-04)
    • Guidelines on fetal growth restriction: a comparison of recent national publications.

      Unterscheider, Julia; O'Donoghue, Keelin; Malone, Fergal D; Rotunda Hospital (2015-03)
      This study aims to compare recommendations from recently published national clinical guidelines for pregnancies complicated by fetal growth restriction (FGR).
    • Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes.

      Horton, Amanda L; Lai, Yinglei; Rouse, Dwight J; Spong, Catherine Y; Leveno, Kenneth J; Varner, Michael W; Mercer, Brian M; Iams, Jay D; Wapner, Ronald J; Sorokin, Yoram; et al. (2015-03)
      This study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation.
    • The association of cord serum cytokines with neurodevelopmental outcomes.

      Varner, Michael W; Marshall, Nicole E; Rouse, Dwight J; Jablonski, Kathleen A; Leveno, Kenneth J; Reddy, Uma M; Mercer, Brian M; Iams, Jay D; Wapner, Ronald J; Sorokin, Yoram; et al. (2015-02)
      To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD).
    • Decision-support guide and use of prenatal genetic testing--reply.

      Kuppermann, Miriam; Norton, Mary E; Rotunda Hospital (2015-01-13)
    • Length of latency with preterm premature rupture of membranes before 32 weeks' gestation.

      Peaceman, Alan M; Lai, Yinglei; Rouse, Dwight J; Spong, Catherine Y; Mercer, Brian M; Varner, Michael W; Thorp, John M; Ramin, Susan M; Malone, Fergal D; O'Sullivan, Mary J; et al. (2015-01)
      The objective of the article is to describe latency for patients with preterm premature membrane rupture (PPROM) between 24(0/7) and 31(6/7) weeks' gestation.
    • Atazanavir exposure is effective during pregnancy regardless of tenofovir use.

      Colbers, Angela; Hawkins, David; Hidalgo-Tenorio, Carmen; van der Ende, Marchina; Gingelmaier, Andrea; Weizsäcker, Katharina; Kabeya, Kabamba; Taylor, Graham; Rockstroh, Jürgen; Lambert, John; et al. (2015)
      We studied the effect of pregnancy on atazanavir pharmacokinetics in the presence and absence of tenofovir.
    • Symptomatic primary cytomegalovirus infection in a HIV-positive pregnant woman.

      Bergin, Sarah; Ferguson, Wendy; Corcoran, Suzanne; Varughese, Allan; Byrne, David; Lawless, Mairead; Eogan, Maeve; Lambert, John S; Clinical Microbiology, Beaumont Hospital, Dublin, Ireland Clinical Microbiology, Rotunda Hospital, Dublin, Ireland sarahbergin1@hotmail.com. (2014-12)
      We describe a case of symptomatic primary Cytomegalovirus infection in a HIV-positive pregnant woman on antiretroviral treatment with a CD4 count >200 × 10(6)/l requiring intravenous ganciclovir. No adverse consequences from ganciclovir or evidence of congenital Cytomegalovirus infection were found.
    • The emergency room at the Rotunda Hospital: evidence of an improving service over the past 3 years.

      Talukdar, S; Eogan, M; Connolly, G; Coulter-Smith, S; Department of Obstetrics and Gynaecology, Rotunda Hospital, Parnell Street, Dublin, Ireland, drsanchilatalukdar@yahoo.co.in. (2014-12)
      This is a retrospective review of the Rotunda Hospital Emergency Room (ER) documentation with respect to attendances for a 4-month period (August-November) in both 2009 and 2012. The aim was to quantify the workload and assess the quality of care offered to patients attending the ER over the two time periods and to highlight any improvements in care after changes were implemented following the initial 2009 review.
    • Accuracy of sonographic chorionicity classification in twin gestations.

      Blumenfeld, Yair J; Momirova, Valerija; Rouse, Dwight J; Caritis, Steve N; Sciscione, Anthony; Peaceman, Alan M; Reddy, Uma M; Varner, Michael W; Malone, Fergal D; Iams, Jay D; et al. (2014-12)
      To evaluate the accuracy of sonographic classification of chorionicity in a large cohort of twins and investigate which factors may be associated with sonographic accuracy.
    • Therapeutic drug monitoring of atazanavir/ritonavir in pregnancy.

      Else, L J; Jackson, V; Brennan, M; Back, D J; Khoo, S H; Coulter-Smith, S; Lambert, J S; Rotunda Hospital Dublin (2014-11)
      Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir/ritonavir (ATV/r) plasma concentrations in a cohort of pregnant women undergoing routine therapeutic drug monitoring (TDM).
    • Cerebral oximetry for cesarean delivery in a Moyamoya case.

      Ajmal, Muhammad; Thornton, Patrick; Department of Anesthesia, Coombe Women and Infants University Hospital, Dublin, Ireland, ajmal_c@hotmail.com. (2014-10)
    • Targeted neonatal echocardiography services: need for standardized training and quality assurance.

      Finan, Emer; Sehgal, Arvind; Khuffash, Afif El; McNamara, Patrick J; Mount Sinai Hospital, Toronto, Ontario, Canada (E.F.); Monash Medical Center, Melbourne, Victoria, Australia (A.S.); Rotunda Hospital, Dublin, Ireland (A.E.K.); Hospital for Sick Children, Toronto, Ontario, Canada (P.J.M.); and Departments of Pediatrics (E.F., P.J.M.) and Physiology (P.J.M.), University of Toronto, Toronto, Ontario, Canada. (2014-10)
      Targeted neonatal echocardiography refers to a focused assessment of myocardial performance and hemodynamics directed by a specific clinical question. It has become the standard of care in many parts of the world, but practice is variable, and there has been a lack of standardized training and evaluation to date. Targeted neonatal echocardiography was first introduced to Canada in 2006. The purpose of this study was to examine the characteristics of targeted neonatal echocardiography practice and training methods in Canadian neonatal intensive care units (NICUs).
    • The dilemma of vaginal breech delivery worldwide.

      Hehir, Mark P; Malone, Fergal D; Rotunda Hospital (2014-09-27)
    • A Comprehensive Echocardiographic Protocol for Assessing Neonatal Right Ventricular Dimensions and Function in the Transitional Period: Normative Data and Z Scores.

      Jain, Amish; Mohamed, Adel; El-Khuffash, Afif; Connelly, Kim A; Dallaire, Frederic; Jankov, Robert P; McNamara, Patrick J; Mertens, Luc; Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: ajain@mtsinai.on.ca. (2014-09-23)
      There is a paucity of echocardiographic data describing right ventricular (RV) dimensions and function in the early transitional newborn period.