• Positive end-expiratory pressure improves survival in a rodent model of cardiopulmonary resuscitation using high-dose epinephrine.

      McCaul, Conán; Kornecki, Alik; Engelberts, Doreen; McNamara, Patrick; Kavanagh, Brian P; Department of Critical Care Medicine, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada. (2009-10)
      Multiple interventions have been tested in models of cardiopulmonary resuscitation (CPR) to optimize drug use, chest compressions, and ventilation. None has studied the effects of positive end-expiratory pressure (PEEP) on outcome. We hypothesized that because PEEP can reverse pulmonary atelectasis, lower pulmonary vascular resistance, and potentially improve cardiac output, its use during CPR would increase survival.