• Clinical pregnancy from a vitrified/warmed human blastocyst

      Emerson, G; Deignan, K; O’Toole, R; Afridi, S; Hughes, C; Roopnarinesingh, R; Mocanu, E (Irish Medical Journal (IMJ), 2013-10)
      The first pregnancy after vitrification of a human blastocyst (day 5 of embryo culture) was reported by Yokota et al. in 2000. Since then more attention has been given to the technique of vitrification and its safe application in ART. To the best of our knowledge, this is the first report of a clinical pregnancy resulting in a live birth from the transfer of a vitrified/ warmed human blastocyst in the Republic of Ireland.
    • Does the Endometrial Scratch improve implantation rates?

      Chawla, S; Purandare, N; Mocanu, E; Hughe, C; Deignan, K; Naasan, M; Kirkham, C (Irish Medical Journal, 2015-07)
      Implantation is one of the most crucial steps in the process of reproduction. Implantation failure is often due to impaired uterine receptivity. Assisted Reproduction techniques are used in order to overcome fertility problems. The endometrial scratch (ES) is a relatively new technique that is said to improve the probability of a successful pregnancy in some women. 1 Although the exact mechanism of this process is still unknown 2 , the use of a catheter to cause local injury to the endometrial lining is suggested to initiate a healing process, thereby attracting immune markers and potentially improving implantation rates. The aim of this study is to assess whether the ES offered randomly to patients attending for ART results in a higher implantation rate in patients that avail of it compared to patients that do not have an endometrial scratch (non-ES).