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    Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane.

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    Authors
    Mahajan, V A
    Ni Chonghaile, M
    Bokhari, S A
    Harte, B H
    Flynn, N M
    Laffey, J G
    Affiliation
    National University of Ireland, Clinical Sciences Institute, and National Centre for Biomedical Engineering Sciences (NCBES), Department of Anaesthesia, Galway, Ireland.
    Issue Date
    2007-06
    MeSH
    Aged
    Ambulatory Surgical Procedures
    Analysis of Variance
    Anesthesia, Inhalation
    Anesthetics, Inhalation
    Cognition Disorders
    Double-Blind Method
    Female
    Humans
    Isoflurane
    Male
    Methyl Ethers
    Neuropsychological Tests
    Orientation
    Prospective Studies
    Time Factors
    Urologic Surgical Procedures
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    Citation
    Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane. 2007, 24 (6):505-10 Eur J Anaesthesiol
    Journal
    European journal of anaesthesiology
    URI
    http://hdl.handle.net/10147/127917
    DOI
    10.1017/S0265021506001980
    PubMed ID
    17202009
    Abstract
    Delayed recovery of cognitive function is a well-recognized phenomenon in older patients. The potential for the volatile anaesthetic used to contribute to alterations in postoperative cognitive function in older patients following minor surgical procedures has not been determined. We compared emergence from isoflurane and sevoflurane anaesthesia in older surgical patients undergoing urological procedures of short duration.
    Seventy-one patients, 60 yr of age or older, undergoing anaesthesia expected to last less than 60 min for ambulatory surgery, were randomly assigned to receive isoflurane or sevoflurane. A standardized anaesthetic protocol was used, with intravenous fentanyl 1 microg kg(-1) and propofol 1.5-2.0 mg kg(-1) administered to induce anaesthesia. Anaesthesia was maintained with either sevoflurane or isoflurane in 65% nitrous oxide and oxygen. Early and intermediate recovery times were recorded. The Mini Mental State Examination and digit repetition forwards and backwards were administered at baseline, and at 1, 3 and 6 h postoperatively, to assess cognitive function.
    There were no between-group differences in (sevoflurane vs. isoflurane, mean +/- standard error of the mean) times to removal of the laryngeal mask airway (7.7 +/- 0.6 vs. 7.1 +/- 0.4 min), verbal response time (10.1 +/- 0.7 vs. 9.9 +/- 0.7 min) and orientation (12.1 +/- 0.7 vs. 12.1 +/- 0.7 min). Intermediate recovery, as measured by time to readiness for discharge from the post anaesthesia care unit (44.9 +/- 1.5 vs. 44.3 +/- 1.5 min), was similar in the two groups. Postoperative indices of cognitive function and attention were comparably reduced at 1 h, but returned to baseline in both groups at 6 h.
    Isoflurane and sevoflurane anaesthesia resulted in similar clinical and neurocognitive recovery profiles in older patients undergoing ambulatory surgical procedures of short duration.
    Item Type
    Article
    Language
    en
    ISSN
    0265-0215
    ae974a485f413a2113503eed53cd6c53
    10.1017/S0265021506001980
    Scopus Count
    Collections
    Galway University Hospitals

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