• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5081
    UlsterS
    5081
    Connacht
    1698
    Munster
    58
    Leinster
    466

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Intravenous glutamine enhances COX-2 activity giving cardioprotection.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    McGuinness, Jonathan
    Neilan, Tom G
    Cummins, Rob
    Sharkasi, Adel
    Bouchier-Hayes, David
    Redmond, J Mark
    Affiliation
    The Royal College of Surgeons in Ireland, Department of Surgery, Beaumont Hospital, Dublin, Ireland.
    Issue Date
    2009-03
    MeSH
    6-Ketoprostaglandin F1 alpha
    Animals
    Cyclooxygenase 2
    Glutamine
    HSP72 Heat-Shock Proteins
    Hemodynamics
    Injections, Intravenous
    Ischemic Preconditioning, Myocardial
    Male
    Malondialdehyde
    Myocardial Reperfusion Injury
    Myocardium
    Nitrates
    Rabbits
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Intravenous glutamine enhances COX-2 activity giving cardioprotection. 2009, 152 (1):140-7 J. Surg. Res.
    Journal
    The Journal of surgical research
    URI
    http://hdl.handle.net/10147/127682
    DOI
    10.1016/j.jss.2008.03.045
    PubMed ID
    18708191
    Abstract
    Preconditioning, a highly evolutionary conserved endogenous protective response, provides the most powerful form of anti-infarct protection known. We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning.
    Male New Zealand white rabbits (n = 28) received either 0.5 g/kg glutamine in 0.9% saline or saline only in divided doses for 3 d. The large marginal branch of the left coronary was occluded for 30 min; cardiac function was assessed during 3 h of reperfusion, and infarct size was measured. 6-Keto-PGF-1alpha, nitrate, and malonaldehyde serum levels were determined. Hearts were taken from a further group of pretreated rabbits (n = 10) to assess myocardial COX-2 and HSP72 levels.
    Glutamine pretreatment resulted in a 39% reduction in infarct size (30.7 +/- 2.0% versus 50.4 +/- 2.1% controls; P < 0.01). Myocardial COX-2 levels were significantly elevated with pretreatment (P < 0.05) and were mirrored by higher serum 6-keto-PGF-1alpha levels prior to ischemia (69 +/- 13 versus 18 +/- 21 pg/mL in controls, P = 0.027). There was no significant difference in myocardial HSP72 or serum nitrate levels following pretreatment, or malonaldehyde levels during reperfusion.
    Glutamine pretreatment confers anti-infarct protection through up-regulation of COX-2, a key mediator of delayed preconditioning protection. Previous confirmation of its clinical safety profile at these doses suggests an acceptable strategy for inducing preconditioning for perioperative protection.
    Item Type
    Article
    Language
    en
    ISSN
    1095-8673
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jss.2008.03.045
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

    Related articles

    • Myocardial protection using an omega-3 fatty acid infusion: quantification and mechanism of action.
    • Authors: McGuinness J, Neilan TG, Sharkasi A, Bouchier-Hayes D, Redmond JM
    • Issue date: 2006 Jul
    • Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2.
    • Authors: Jiang X, Shi E, Nakajima Y, Sato S, Ohno K, Yue H
    • Issue date: 2005 May 17
    • Preconditioning effects of steroids and hyperoxia on cardiac ischemia-reperfusion injury and vascular reactivity.
    • Authors: Kaljusto ML, Stensløkken KO, Mori T, Panchenko A, Frantzen ML, Valen G, Vaage J
    • Issue date: 2008 Mar
    • [Protective effect of heat-shock protein 27 on myocardium with isoflurane preconditioning in myocardial ischemia/reperfusion injury of myocardium in rabbit].
    • Authors: Ran K, Zhu R, Lu XH, Zou DQ, Li H, Chang YT
    • Issue date: 2007 Nov
    • Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB.
    • Authors: Feng J, Lucchinetti E, Fischer G, Zhu M, Zaugg K, Schaub MC, Zaugg M
    • Issue date: 2008 Apr 1
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.