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dc.contributor.authorO'Sullivan, Eoin P
dc.contributor.authorBehan, Lucy-Ann
dc.contributor.authorKing, Tom F J
dc.contributor.authorHardiman, Orla
dc.contributor.authorSmith, Diarmuid
dc.date.accessioned2011-04-07T10:10:22Z
dc.date.available2011-04-07T10:10:22Z
dc.date.issued2009-05
dc.identifier.citationA case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis. 2009, 111 (4):384-6 Clin Neurol Neurosurgen
dc.identifier.issn1872-6968
dc.identifier.pmid19150172
dc.identifier.doi10.1016/j.clineuro.2008.11.006
dc.identifier.urihttp://hdl.handle.net/10147/127667
dc.description.abstractAntibodies against glutamic acid decarboxylase (GAD) are involved in the pathophysiology of stiff-person syndrome (SPS) and type 1 diabetes. GAD catalyses the conversion of glutamate to gamma-aminobutyric acid (GABA). GABA acts as a neurotransmitter between neurones, while in pancreatic beta cells it plays an integral role in normal insulin secretion, hence the clinical presentation of muscular spasms in SPS and insulin deficiency in diabetes. Despite this apparent major overlap in pathophysiology, SPS only rarely occurs in individuals with type 1 diabetes. We report the case of a 41-year-old man presenting with a simultaneous diagnosis of both these conditions. His case is unusual in that it is the first reported case in the literature of these conditions occurring in someone with celiac disease (CD) and dermatitis herpetiformis. We discuss why SPS and type 1 diabetes co-exist in only a minority of cases and speculate on the underlying mechanism of the association with CD and dermatitis herpetiformis in our patient.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshCeliac Disease
dc.subject.meshComorbidity
dc.subject.meshDermatitis Herpetiformis
dc.subject.meshDiabetes Mellitus, Type 1
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshStiff-Person Syndrome
dc.titleA case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diabetes and Endocrinology, Beaumont Hospital, Dublin 9, Ireland. eoinosullivan@beaumont.ieen
dc.identifier.journalClinical neurology and neurosurgeryen
dc.description.provinceLeinster
html.description.abstractAntibodies against glutamic acid decarboxylase (GAD) are involved in the pathophysiology of stiff-person syndrome (SPS) and type 1 diabetes. GAD catalyses the conversion of glutamate to gamma-aminobutyric acid (GABA). GABA acts as a neurotransmitter between neurones, while in pancreatic beta cells it plays an integral role in normal insulin secretion, hence the clinical presentation of muscular spasms in SPS and insulin deficiency in diabetes. Despite this apparent major overlap in pathophysiology, SPS only rarely occurs in individuals with type 1 diabetes. We report the case of a 41-year-old man presenting with a simultaneous diagnosis of both these conditions. His case is unusual in that it is the first reported case in the literature of these conditions occurring in someone with celiac disease (CD) and dermatitis herpetiformis. We discuss why SPS and type 1 diabetes co-exist in only a minority of cases and speculate on the underlying mechanism of the association with CD and dermatitis herpetiformis in our patient.


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