Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.
AffiliationMolecular Medicine Laboratories, RCSI Education and Research Centre, Beaumont Hospital, Dublin, Ireland. email@example.com
Cell Culture Techniques
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
Large-Conductance Calcium-Activated Potassium Channels
Reverse Transcriptase Polymerase Chain Reaction
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CitationActivation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells. 2009, 50 (1):194-202 Invest. Ophthalmol. Vis. Sci.
JournalInvestigative ophthalmology & visual science
AbstractThe results show that hypotonic stress of human LC cells activates SAC and Ca(2+)-dependent maxi-K(+) channels and that the increase in [Ca(2+)](i) during cell swelling was predominantly from extracellular sources (or intracellular stores other than the endoplasmic reticulum). These findings improve the understanding of how LC cells respond to cell membrane stretch. Further experiments in this area may reveal future targets for novel therapeutic intervention in the management of glaucoma.