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    Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.

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    Authors
    Keogan, M T
    Affiliation
    Department of Immunology, Beaumont Hospital, Dublin, Ireland. marykeogan@beaumont.ie
    Issue Date
    2009-04
    MeSH
    Behcet Syndrome
    Diagnosis, Differential
    Female
    Genital Diseases, Female
    Genital Diseases, Male
    Humans
    Male
    Recurrence
    Stomatitis, Aphthous
    Ulcer
    
    Metadata
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    Citation
    Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome. 2009, 156 (1):1-11 Clin. Exp. Immunol.
    Journal
    Clinical and experimental immunology
    URI
    http://hdl.handle.net/10147/127650
    DOI
    10.1111/j.1365-2249.2008.03857.x
    PubMed ID
    19210521
    Additional Links
    http://www.jbc.org/content/284/25/16891.full.pdf+html
    Abstract
    Patients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema multiforme, erosive lichen planus). Behçet's syndrome is a multi-system vasculitis of unknown aetiology for which there is no diagnostic test. Diagnosis is based on agreed clinical criteria that require recurrent oral ulcers and two of the following: recurrent genital ulcers, ocular inflammation, defined skin lesions and pathergy. The condition can present with a variety of symptoms, hence a high index of suspicion is necessary. The most common presentation is with recurrent mouth ulcers, often with genital ulcers; however, it may take some years before diagnostic criteria are met. All patients with idiopathic orogenital ulcers should be kept under review, with periodic focused assessment to detect evolution into Behçet's disease. There is often a delay of several years between patients fulfilling diagnostic criteria and a diagnosis being made, which may contribute to the morbidity of this condition. Despite considerable research effort, the aetiology and pathogenesis of this condition remains enigmatic.
    Item Type
    Article
    Language
    en
    ISSN
    1365-2249
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2008.03857.x
    Scopus Count
    Collections
    Beaumont Hospital

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