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    Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?

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    Authors
    Doherty, Glen A
    Murray, Frank E
    Affiliation
    Beaumont Hospital, Department of Gastroenterology, Beaumont Road, Dublin, D8, Ireland. glen_doherty@hotmail.com
    Issue Date
    2009-02
    MeSH
    Animals
    Anti-Inflammatory Agents, Non-Steroidal
    Anticarcinogenic Agents
    Clinical Trials as Topic
    Colorectal Neoplasms
    Cyclooxygenase 2
    Cyclooxygenase Inhibitors
    Disease Models, Animal
    Drug Delivery Systems
    Humans
    
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    Citation
    Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? 2009, 13 (2):209-18 Expert Opin. Ther. Targets
    Journal
    Expert opinion on therapeutic targets
    URI
    http://hdl.handle.net/10147/127645
    DOI
    10.1517/14728220802653631
    PubMed ID
    19236238
    Abstract
    COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance angiogenesis, promoting tumour growth and metastasis. There are ample data from animal models and human studies to demonstrate enhanced tumour progression associated with COX-2 activity in cancer cells. Conversely, NSAIDs including aspirin inhibit COX-2 and, therefore, have anti-neoplastic properties. There has been sustained interest in COX-2 as a chemopreventive target in colorectal cancer (CRC) and although both aspirin and COX-2 selective NSAIDs have demonstrated efficacy, adverse effects have limited their widespread adoption. In particular, evidence of the cardiovascular effects of COX-2 selective inhibitors has led to questioning of the suitability of COX-2 as a target for chemoprevention. This review examines the basis for targeting COX-2 in CRC chemoprevention, evaluates the efficacy and safety of the approach and examines future strategies in this area.
    Item Type
    Article
    Language
    en
    ISSN
    1744-7631
    ae974a485f413a2113503eed53cd6c53
    10.1517/14728220802653631
    Scopus Count
    Collections
    Beaumont Hospital

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