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    Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency.

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    Authors
    Kelly, Emer
    Greene, Catherine M
    Carroll, Tomás P
    McElvaney, Noel G
    O'Neill, Shane J
    Affiliation
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
    Issue Date
    2009-06-19
    MeSH
    Base Sequence
    Cell Line
    DNA Primers
    Endoplasmic Reticulum
    Gene Expression
    Genetic Variation
    Glutathione Peroxidase
    Heat-Shock Proteins
    Humans
    Membrane Proteins
    NF-kappa B
    Promoter Regions, Genetic
    Recombinant Proteins
    Selenium
    Selenoproteins
    Stress, Physiological
    Transfection
    alpha 1-Antitrypsin
    alpha 1-Antitrypsin Deficiency
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    Citation
    Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. 2009, 284 (25):16891-7 J. Biol. Chem.
    Journal
    The Journal of biological chemistry
    URI
    http://hdl.handle.net/10147/127627
    DOI
    10.1074/jbc.M109.006288
    PubMed ID
    19398551
    Additional Links
    http://www.jbc.org/content/284/25/16891.full.pdf+html
    Abstract
    Z alpha(1)-antitrypsin (ZAAT) deficiency is a disease associated with emphysematous lung disease and also with liver disease. The liver disease of AAT deficiency is associated with endoplasmic reticulum (ER) stress. SEPS1 is a selenoprotein that, through a chaperone activity, decreases ER stress. To determine the effect of SEPS1 on ER stress in ZAAT deficiency, we measured activity of the grp78 promoter and levels of active ATF6 as markers of the unfolded protein response in HepG2 cells transfected with the mutant form of AAT, a ZAAT transgene. We evaluated levels of NFkappaB activity as a marker of the ER overload response. To determine the effect of selenium supplementation on the function of SEPS1, we investigated glutathione peroxidase activity, grp78 promoter activity, and NFkappaB activity in the presence or absence of selenium. SEPS1 reduced levels of active ATF6. Overexpression of SEPS1 also inhibited grp78 promoter and NFkappaB activity, and this effect was enhanced in the presence of selenium supplementation. This finding demonstrates a role for SEPS1 in ZAAT deficiency and suggests a possible therapeutic potential for selenium supplementation.
    Item Type
    Article
    Language
    en
    ISSN
    1083-351X
    ae974a485f413a2113503eed53cd6c53
    10.1074/jbc.M109.006288
    Scopus Count
    Collections
    Beaumont Hospital

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