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dc.contributor.authorOlaitan, Oyedolamu K
dc.contributor.authorZimmermann, Jose A
dc.contributor.authorShields, William P
dc.contributor.authorRodriguez-Navas, Guillermo
dc.contributor.authorAwan, Atif
dc.contributor.authorMohan, Ponnusamy
dc.contributor.authorLittle, Dilly M
dc.contributor.authorHickey, David P
dc.date.accessioned2011-04-07T08:42:20Z
dc.date.available2011-04-07T08:42:20Z
dc.date.issued2010-02
dc.identifier.citationLong-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation. 2010, 14 (1):87-92 Pediatr Transplanten
dc.identifier.issn1399-3046
dc.identifier.pmid19309452
dc.identifier.doi10.1111/j.1399-3046.2009.01138.x
dc.identifier.urihttp://hdl.handle.net/10147/127618
dc.description.abstractTo report the long-term outcome of deceased donor kidney transplantation in children with emphasis on the use of an intensive initial immunosuppression protocol using R-ATG as antibody induction. Between January 1991 and December 1997, 82 deceased donor kidney transplantations were performed in 75 pediatric recipients. Mean recipient age at transplantation was 12.9 yr and the mean follow-up period was 12.6 yr. All patients received quadruple immunosuppression with steroid, cyclosporine, azathioprine, and antibody induction using R-ATG-Fresenius. Actual one, five, and 10 yr patient survival rates were 99%, 97%, and 94%, respectively; only one patient (1.2%) developed PTLD. Actual one, five, and 10 yr overall graft survival rates were 84%, 71%, and 50%, respectively; there were five cases (6%) of graft thrombosis and the actual immunological graft survival rates were 91%, 78%, and 63% at one, five, and 10 yr, respectively. The use of an intensive initial immunosuppression protocol with R-ATG as antibody induction is safe and effective in pediatric recipients of deceased donor kidneys with excellent immunological graft survival without an increase in PTLD or other neoplasms over a minimum 10-yr follow up.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshGraft Rejection
dc.subject.meshGraft Survival
dc.subject.meshHumans
dc.subject.meshImmunosuppression
dc.subject.meshImmunosuppressive Agents
dc.subject.meshIreland
dc.subject.meshKidney Transplantation
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Factors
dc.subject.meshSurvival Rate
dc.subject.meshTime Factors
dc.subject.meshTissue Donors
dc.subject.meshTreatment Outcome
dc.subject.meshYoung Adult
dc.titleLong-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation.en
dc.typeArticleen
dc.contributor.departmentNational Kidney and Pancreas Transplantation Centre, Beaumont Hospital, Dublin, Ireland. oyedolamu@yahoo.comen
dc.identifier.journalPediatric transplantationen
dc.description.provinceLeinster
html.description.abstractTo report the long-term outcome of deceased donor kidney transplantation in children with emphasis on the use of an intensive initial immunosuppression protocol using R-ATG as antibody induction. Between January 1991 and December 1997, 82 deceased donor kidney transplantations were performed in 75 pediatric recipients. Mean recipient age at transplantation was 12.9 yr and the mean follow-up period was 12.6 yr. All patients received quadruple immunosuppression with steroid, cyclosporine, azathioprine, and antibody induction using R-ATG-Fresenius. Actual one, five, and 10 yr patient survival rates were 99%, 97%, and 94%, respectively; only one patient (1.2%) developed PTLD. Actual one, five, and 10 yr overall graft survival rates were 84%, 71%, and 50%, respectively; there were five cases (6%) of graft thrombosis and the actual immunological graft survival rates were 91%, 78%, and 63% at one, five, and 10 yr, respectively. The use of an intensive initial immunosuppression protocol with R-ATG as antibody induction is safe and effective in pediatric recipients of deceased donor kidneys with excellent immunological graft survival without an increase in PTLD or other neoplasms over a minimum 10-yr follow up.


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