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    Long-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation.

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    Authors
    Olaitan, Oyedolamu K
    Zimmermann, Jose A
    Shields, William P
    Rodriguez-Navas, Guillermo
    Awan, Atif
    Mohan, Ponnusamy
    Little, Dilly M
    Hickey, David P
    Affiliation
    National Kidney and Pancreas Transplantation Centre, Beaumont Hospital, Dublin, Ireland. oyedolamu@yahoo.com
    Issue Date
    2010-02
    MeSH
    Adolescent
    Adult
    Aged
    Child
    Child, Preschool
    Dose-Response Relationship, Drug
    Female
    Follow-Up Studies
    Graft Rejection
    Graft Survival
    Humans
    Immunosuppression
    Immunosuppressive Agents
    Ireland
    Kidney Transplantation
    Male
    Middle Aged
    Retrospective Studies
    Risk Factors
    Survival Rate
    Time Factors
    Tissue Donors
    Treatment Outcome
    Young Adult
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    Citation
    Long-term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation. 2010, 14 (1):87-92 Pediatr Transplant
    Journal
    Pediatric transplantation
    URI
    http://hdl.handle.net/10147/127618
    DOI
    10.1111/j.1399-3046.2009.01138.x
    PubMed ID
    19309452
    Abstract
    To report the long-term outcome of deceased donor kidney transplantation in children with emphasis on the use of an intensive initial immunosuppression protocol using R-ATG as antibody induction. Between January 1991 and December 1997, 82 deceased donor kidney transplantations were performed in 75 pediatric recipients. Mean recipient age at transplantation was 12.9 yr and the mean follow-up period was 12.6 yr. All patients received quadruple immunosuppression with steroid, cyclosporine, azathioprine, and antibody induction using R-ATG-Fresenius. Actual one, five, and 10 yr patient survival rates were 99%, 97%, and 94%, respectively; only one patient (1.2%) developed PTLD. Actual one, five, and 10 yr overall graft survival rates were 84%, 71%, and 50%, respectively; there were five cases (6%) of graft thrombosis and the actual immunological graft survival rates were 91%, 78%, and 63% at one, five, and 10 yr, respectively. The use of an intensive initial immunosuppression protocol with R-ATG as antibody induction is safe and effective in pediatric recipients of deceased donor kidneys with excellent immunological graft survival without an increase in PTLD or other neoplasms over a minimum 10-yr follow up.
    Item Type
    Article
    Language
    en
    ISSN
    1399-3046
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1399-3046.2009.01138.x
    Scopus Count
    Collections
    Beaumont Hospital

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