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    Psychosis and autism: magnetic resonance imaging study of brain anatomy.

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    Authors
    Toal, Fiona
    Bloemen, Oswald J N
    Deeley, Quinton
    Tunstall, Nigel
    Daly, Eileen M
    Page, Lisa
    Brammer, Michael J
    Murphy, Kieran C
    Murphy, Declan G M
    Affiliation
    Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. fiona.toal@forensicare.vic.gov.au
    Issue Date
    2009-05
    MeSH
    Adult
    Autistic Disorder
    Brain
    Brain Mapping
    Humans
    Intelligence Tests
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Psychiatric Status Rating Scales
    Psychotic Disorders
    Risk Factors
    Schizophrenia
    Young Adult
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    Metadata
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    Citation
    Psychosis and autism: magnetic resonance imaging study of brain anatomy. 2009, 194 (5):418-25 Br J Psychiatry
    Journal
    The British journal of psychiatry : the journal of mental science
    URI
    http://hdl.handle.net/10147/127608
    DOI
    10.1192/bjp.bp.107.049007
    PubMed ID
    19407271
    Additional Links
    http://bjp.rcpsych.org/cgi/reprint/194/5/418
    Abstract
    Autism-spectrum disorder is increasingly recognised, with recent studies estimating that 1% of children in South London are affected. However, the biology of comorbid mental health problems in people with autism-spectrum disorder is poorly understood.
    To investigate the brain anatomy of people with autism-spectrum disorder with and without psychosis.
    We used in vivo magnetic resonance imaging and compared 30 adults with autism-spectrum disorder (14 with a history psychosis) and 16 healthy controls.
    Compared with controls both autism-spectrum disorder groups had significantly less grey matter bilaterally in the temporal lobes and the cerebellum. In contrast, they had increased grey matter in striatal regions. However, those with psychosis also had a significant reduction in grey matter content of frontal and occipital regions. Contrary to our expectation, within autism-spectrum disorder, comparisons revealed that psychosis was associated with a reduction in grey matter of the right insular cortex and bilaterally in the cerebellum extending into the fusiform gyrus and the lingual gyrus.
    The presence of neurodevelopmental abnormalities normally associated with autism-spectrum disorder might represent an alternative 'entry-point' into a final common pathway of psychosis.
    Item Type
    Article
    Language
    en
    ISSN
    1472-1465
    ae974a485f413a2113503eed53cd6c53
    10.1192/bjp.bp.107.049007
    Scopus Count
    Collections
    Beaumont Hospital

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