Show simple item record

dc.contributor.authorChotirmall, Sanjay Haresh
dc.contributor.authorWatts, Michael
dc.contributor.authorBranagan, Peter
dc.contributor.authorDonegan, Ciaran F
dc.contributor.authorMoore, Allan
dc.contributor.authorMcElvaney, Noel Gerard
dc.date.accessioned2011-04-06T14:54:55Z
dc.date.available2011-04-06T14:54:55Z
dc.date.issued2009-05
dc.identifier.citationDiagnosis and management of asthma in older adults. 2009, 57 (5):901-9 J Am Geriatr Socen
dc.identifier.issn1532-5415
dc.identifier.pmid19484848
dc.identifier.urihttp://hdl.handle.net/10147/127507
dc.description.abstractDespite comprehensive guidelines established by the European Global Initiative for Asthma and the U.S. National Asthma Education and Prevention Program on the diagnosis and management of asthma, its mortality in older adults continues to rise. Diagnostic and therapeutic problems contribute to older patients being inadequately treated. The diagnosis of asthma rests on the history and characteristic pulmonary function testing (PFT) with the demonstration of reversible airway obstruction, but there are unique problems in performing this test in older patients and in its interpretation. This review aims to address the difficulties in performing and interpreting PFT in older patients because of the effects of age-related changes in lung function on respiratory physiology. The concept of "airway remodeling" resulting in "fixed obstructive" PFT and the relevance of atopy in older people with asthma are assessed. There are certain therapeutic issues unique to older patients with asthma, including the increased probability of adverse effects in the setting of multiple comorbidities and issues surrounding effective drug delivery. The use of beta 2-agonist, anticholinergic, corticosteroid, and anti-immunoglobulin E treatments are discussed in the context of these therapeutic issues.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAnti-Asthmatic Agents
dc.subject.meshAsthma
dc.subject.meshDrug Delivery Systems
dc.subject.meshHumans
dc.subject.meshRespiratory Function Tests
dc.titleDiagnosis and management of asthma in older adults.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, Respiratory Research Division, Education & Research Centre, Beaumont Hospital, Dublin 9, Republic of Ireland. schotirmall@rcsi.ieen
dc.identifier.journalJournal of the American Geriatrics Societyen
dc.description.provinceLeinster
html.description.abstractDespite comprehensive guidelines established by the European Global Initiative for Asthma and the U.S. National Asthma Education and Prevention Program on the diagnosis and management of asthma, its mortality in older adults continues to rise. Diagnostic and therapeutic problems contribute to older patients being inadequately treated. The diagnosis of asthma rests on the history and characteristic pulmonary function testing (PFT) with the demonstration of reversible airway obstruction, but there are unique problems in performing this test in older patients and in its interpretation. This review aims to address the difficulties in performing and interpreting PFT in older patients because of the effects of age-related changes in lung function on respiratory physiology. The concept of "airway remodeling" resulting in "fixed obstructive" PFT and the relevance of atopy in older people with asthma are assessed. There are certain therapeutic issues unique to older patients with asthma, including the increased probability of adverse effects in the setting of multiple comorbidities and issues surrounding effective drug delivery. The use of beta 2-agonist, anticholinergic, corticosteroid, and anti-immunoglobulin E treatments are discussed in the context of these therapeutic issues.


This item appears in the following Collection(s)

Show simple item record