Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.
| dc.contributor.author | Robb, W B | |
| dc.contributor.author | Condron, C | |
| dc.contributor.author | Moriarty, M | |
| dc.contributor.author | Walsh, T N | |
| dc.contributor.author | Bouchier-Hayes, D J | |
| dc.date.accessioned | 2011-04-06T14:44:23Z | |
| dc.date.available | 2011-04-06T14:44:23Z | |
| dc.date.issued | 2010-03 | |
| dc.identifier.citation | Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice. 2010, 179 (1):99-105 Ir J Med Sci | en |
| dc.identifier.issn | 1863-4362 | |
| dc.identifier.pmid | 19609640 | |
| dc.identifier.doi | 10.1007/s11845-009-0389-2 | |
| dc.identifier.uri | http://hdl.handle.net/10147/127499 | |
| dc.description.abstract | The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy. | |
| dc.description.abstract | Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis. | |
| dc.description.abstract | Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020). | |
| dc.description.abstract | This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation. | |
| dc.language.iso | en | en |
| dc.title | Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Dublin, Ireland. wrobb@rcsi.ie | en |
| dc.identifier.journal | Irish journal of medical science | en |
| dc.description.province | Leinster | |
| html.description.abstract | The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy. | |
| html.description.abstract | Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis. | |
| html.description.abstract | Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020). | |
| html.description.abstract | This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation. |