• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4708
    UlsterS
    4708
    Connacht
    1607
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Robb, W B
    Condron, C
    Moriarty, M
    Walsh, T N
    Bouchier-Hayes, D J
    Affiliation
    Department of Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Dublin, Ireland. wrobb@rcsi.ie
    Issue Date
    2010-03
    
    Metadata
    Show full item record
    Citation
    Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice. 2010, 179 (1):99-105 Ir J Med Sci
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/127499
    DOI
    10.1007/s11845-009-0389-2
    PubMed ID
    19609640
    Abstract
    The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.
    Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis.
    Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020).
    This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.
    Item Type
    Article
    Language
    en
    ISSN
    1863-4362
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-009-0389-2
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

    Related articles

    • Regulation of transforming growth factor-beta1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis.
    • Authors: Gurujeyalakshmi G, Hollinger MA, Giri SN
    • Issue date: 1998 Mar
    • [Experimental study on effect of Huaxian Decoction treating bleomycin-induced pulmonary fibrosis in mice].
    • Authors: Wang SJ, Bai W, Wang CL
    • Issue date: 2007 Apr
    • Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
    • Authors: Gurujeyalakshmi G, Wang Y, Giri SN
    • Issue date: 2000 Apr
    • [Effects of andrographolide on the concentration of cytokines in BALF and the expressions of type I and III collagen mRNA in lung tissue in bleomycin-induced rat pulmonary fibrosis].
    • Authors: Zhu HL, Huang CL, Wang WJ, Zhan XQ, Fan XM
    • Issue date: 2011 Jul
    • Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse.
    • Authors: Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, Arguiri E, Shuvaev VV, Sun J, Cengel K, Solomides CC, Christofidou-Solomidou M
    • Issue date: 2006 Nov
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.