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    Anaplastic thyroid cancer, tumorigenesis and therapy.

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    Authors
    O'Neill, J P
    Power, D
    Condron, C
    Bouchier-Hayes, D
    Walsh, M
    Affiliation
    The Department of Otolaryngology, The Royal College of Surgeons in Ireland, Beaumont Hospital, The Education and Research Building, Beaumont, Dublin 9, Ireland. joneill@rcsi.ie
    Issue Date
    2010-03
    
    Metadata
    Show full item record
    Citation
    Anaplastic thyroid cancer, tumorigenesis and therapy. 2010, 179 (1):9-15 Ir J Med Sci
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/127488
    DOI
    10.1007/s11845-009-0364-y
    PubMed ID
    19662494
    Abstract
    Anaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies.
    An extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings.
    Significant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.
    Item Type
    Article
    Language
    en
    ISSN
    1863-4362
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-009-0364-y
    Scopus Count
    Collections
    Beaumont Hospital

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