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dc.contributor.authorO'Seaghdha, C M
dc.contributor.authorMcQuillan, R
dc.contributor.authorMoran, A M
dc.contributor.authorLavin, P
dc.contributor.authorDorman, A
dc.contributor.authorO'Kelly, P
dc.contributor.authorMohan, D M
dc.contributor.authorLittle, P
dc.contributor.authorHickey, D P
dc.contributor.authorConlon, P J
dc.date.accessioned2011-04-06T14:17:52Z
dc.date.available2011-04-06T14:17:52Z
dc.date.issued2011-04-06T14:17:52Z
dc.identifier.citationHigher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection., 23 (4):462-8 Clin Transplanten
dc.identifier.issn1399-0012
dc.identifier.pmid19681975
dc.identifier.doi10.1111/j.1399-0012.2009.01021.x
dc.identifier.urihttp://hdl.handle.net/10147/127487
dc.description.abstractWe analyzed the association between whole-blood trough tacrolimus (TAC) levels in the first days post-kidney transplant and acute cellular rejection (ACR) rates. Four hundred and sixty-four consecutive, deceased-donor kidney transplant recipients were included. All were treated with a combination of TAC, mycophenolate mofetil and prednisolone. Patients were analyzed in four groups based on quartiles of the mean TAC on days 2 and 5 post-transplant: Group 1: median TAC 11 ng/mL (n = 122, range 2-13.5 ng/mL), Group 2: median 17 ng/mL (n = 123, range 14-20 ng/mL), Group 3: median 24 ng/mL (n = 108, range 20.5-27 ng/mL) and Group 4: median 33.5 ng/mL (n = 116, range 27.5-77.5 ng/mL). A graded reduction in the rates of ACR was observed for each incremental days 2-5 TAC. The one-yr ACR rate was 24.03% (95% CI 17.26-32.88), 22.20% (95% CI 15.78-30.70), 13.41% (95% CI 8.15-21.63) and 8.69% (95% CI 4.77-15.55) for Groups 1-4, respectively (p = 0.003). This study suggests that higher early TACs are associated with reduced rates of ACR at one yr.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCadaver
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDrug Monitoring
dc.subject.meshDrug Therapy, Combination
dc.subject.meshFemale
dc.subject.meshGraft Rejection
dc.subject.meshGraft Survival
dc.subject.meshHumans
dc.subject.meshImmunosuppressive Agents
dc.subject.meshKidney Transplantation
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMycophenolic Acid
dc.subject.meshPrednisolone
dc.subject.meshRetrospective Studies
dc.subject.meshTacrolimus
dc.subject.meshYoung Adult
dc.titleHigher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection.en
dc.typeArticleen
dc.contributor.departmentDepartment of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalClinical transplantationen
dc.description.provinceLeinster
html.description.abstractWe analyzed the association between whole-blood trough tacrolimus (TAC) levels in the first days post-kidney transplant and acute cellular rejection (ACR) rates. Four hundred and sixty-four consecutive, deceased-donor kidney transplant recipients were included. All were treated with a combination of TAC, mycophenolate mofetil and prednisolone. Patients were analyzed in four groups based on quartiles of the mean TAC on days 2 and 5 post-transplant: Group 1: median TAC 11 ng/mL (n = 122, range 2-13.5 ng/mL), Group 2: median 17 ng/mL (n = 123, range 14-20 ng/mL), Group 3: median 24 ng/mL (n = 108, range 20.5-27 ng/mL) and Group 4: median 33.5 ng/mL (n = 116, range 27.5-77.5 ng/mL). A graded reduction in the rates of ACR was observed for each incremental days 2-5 TAC. The one-yr ACR rate was 24.03% (95% CI 17.26-32.88), 22.20% (95% CI 15.78-30.70), 13.41% (95% CI 8.15-21.63) and 8.69% (95% CI 4.77-15.55) for Groups 1-4, respectively (p = 0.003). This study suggests that higher early TACs are associated with reduced rates of ACR at one yr.


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